Description

4-Quinolinepropanoic Acid, α-[[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino]-, (αr)- is a sophisticated, optically active Fmoc-protected amino acid derivative designed for advanced organic synthesis. This compound is a critical chiral building block, enabling the precise construction of complex molecular architectures with high stereochemical fidelity. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, particularly in the fields of peptide mimetics and small molecule drug discovery.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected unnatural amino acid, it serves as a key monomer for introducing the quinoline moiety into peptide chains, enabling the creation of novel bioactive peptides.
• Medicinal Chemistry & Drug Discovery: Acts as a versatile chiral intermediate for synthesizing targeted libraries of compounds for high-throughput screening against various biological targets.
• Chemical Biology Research: Used in the synthesis of activity-based probes and molecular tools to study enzyme function and protein-protein interactions.
• Asymmetric Synthesis: Employed as a chiral scaffold or auxiliary in catalytic asymmetric reactions to generate enantiomerically pure compounds.
• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of potential Active Pharmaceutical Ingredients (APIs) with quinoline-based pharmacophores.

Basic Information

Item	Details
Product Name	4-Quinolinepropanoic Acid, α-[[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino]-, (αr)-
CAS No.	1997440-75-1
Molecular Formula	C27H24N2O4
Molecular Weight	440.49 g/mol
Synonyms	(R)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(quinolin-4-yl)propanoic acid; Fmoc-(R)-3-(4-Quinolyl)-alanine; Fmoc-(R)-3-(quinolin-4-yl)alanine; Fmoc-R(3-Quin-4-yl)Ala-OH; (αR)-α-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-4-quinolinepropanoic acid; UNII-Contact for details; (R)-Fmoc-3-(4-quinolyl)alanine
EINECS	Contact for details

Quality Control

Every batch of our 4-Quinolinepropanoic Acid derivative is manufactured under strict quality management systems. We employ advanced analytical techniques including HPLC, NMR, and mass spectrometry to ensure high chiral purity and chemical identity. Certificates of Analysis (COA) detailing specific batch results for assay, enantiomeric excess, and impurity profiles are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.