Description

2-Thiophenepropanoic Acid, 5-Chloro-α-[[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino]-, (αs)- is a sophisticated, non-natural amino acid derivative featuring a thiophene side chain and a fluorenylmethyloxycarbonyl (Fmoc) protecting group. This compound matters as a critical building block in solid-phase peptide synthesis (SPPS), enabling the precise incorporation of modified amino acids to create peptides with enhanced stability, bioavailability, or specific binding properties. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel therapeutic peptides, peptidomimetics, and chemical biology probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid, it serves as a key monomer for the automated synthesis of custom peptides containing the 5-chloro-2-thienylalanine residue.
• Pharmaceutical R&D: Used in the research and development of novel peptide-based drugs, where the thiophene moiety can modulate pharmacokinetic properties and receptor interactions.
• Peptidomimetic Design: Acts as a scaffold for creating peptidomimetics—molecules that mimic peptides but with improved metabolic stability and oral bioavailability.
• Chemical Biology & Proteomics: Employed to synthesize peptide tags, substrates, or inhibitors for studying enzyme function, protein-protein interactions, and cellular pathways.
• Material Science: Potential use in the synthesis of functionalized polymers or surface coatings where peptide sequences guide self-assembly or specific binding.

Basic Information

Product Name	2-Thiophenepropanoic Acid, 5-Chloro-α-[[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino]-, (αs)-
CAS No.	1997405-70-5
Molecular Formula	C22H18ClNO4S
Molecular Weight	427.90 g/mol
Synonyms	Fmoc-5-chloro-2-thienylalanine; Fmoc-5-Cl-2-Thi-Ala-OH; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(5-chlorothiophen-2-yl)propanoic acid; Fmoc-5-chlorothien-2-yl-Ala-OH; N-α-Fmoc-5-chloro-2-thienylalanine; 5-Chloro-2-thienylalanine Fmoc derivative; Fmoc-L-5-chloro-2-thienylalanine; Fmoc-(5-Cl)-2-Thi
EINECS	Contact for details

Quality Control

Our 2-Thiophenepropanoic Acid, 5-Chloro-α-[[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino]-, (αs)- is produced under strict quality management protocols to ensure the high purity and chiral integrity required for sensitive peptide synthesis. Each batch undergoes comprehensive analytical characterization, including HPLC for purity, chiral analysis for enantiomeric excess, and NMR for structural confirmation. Certificates of Analysis (COA) detailing all test results are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry environment. This product is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to ambient conditions or light may lead to decomposition or reduced purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.