Description

3-Bromo-4-Chloro-2-Fluorophenylboronic Acid is a high-purity, multi-halogenated boronic acid derivative serving as a critical building block in modern synthetic chemistry. Its value lies in its unique halogen substitution pattern, which enables precise cross-coupling reactions for constructing complex molecular architectures. This advanced intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing new active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly in oncology and CNS therapeutic areas.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, where the halogenated aromatic core contributes to biological activity.
• Material Science Research: Employed in the creation of functionalized polymers, liquid crystals, and organic electronic materials.
• Chemical Biology Probes: Serves as a versatile handle for bioconjugation and the synthesis of molecular probes for diagnostic applications.
• Custom Synthesis & Contract Manufacturing: An important starting material for fine chemical and custom synthesis houses serving global R&D pipelines.

Basic Information

Product Name	3-Bromo-4-Chloro-2-Fluorophenylboronic Acid
CAS No.	1987879-74-2
Molecular Formula	C6H4BBrClFO2
Molecular Weight	253.26 g/mol
Synonyms	(3-Bromo-4-chloro-2-fluorophenyl)boronic acid; 2-Fluoro-3-bromo-4-chlorophenylboronic acid; B-(3-Bromo-4-chloro-2-fluorophenyl)boronic acid; 1987879-74-2; Boronic acid, B-(3-bromo-4-chloro-2-fluorophenyl)-; 3-Bromo-4-chloro-2-fluorobenzeneboronic acid
EINECS	Contact for details

Quality Control

Our 3-Bromo-4-Chloro-2-Fluorophenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and Karl Fischer titration for moisture content, to ensure it meets the stringent requirements for advanced synthetic applications. Certificates of Analysis (COA) documenting all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.