Description

Teplow'S Amyloid β-Protein (1-42) (Scrambled Ii) Trifluoroacetate Salt is a high-purity synthetic peptide sequence designed for advanced biochemical and neurological research. This compound serves as a critical control or reference material in studies investigating the structure, aggregation, and toxicity of amyloid-beta peptides, which are central to Alzheimer's disease pathology. It is essential for researchers and developers in pharmaceutical R&D, academic institutions, and diagnostic kit manufacturing who require reliable, well-characterized reagents for assay validation and mechanistic studies.

Application

• Neuroscience Research: Used as a scrambled control peptide in studies of amyloid-beta (1-42) aggregation, fibril formation, and neurotoxicity.
• Drug Discovery & Screening: Serves as a critical reference standard in high-throughput screening assays to identify potential inhibitors of amyloid-beta aggregation.
• Assay Development & Validation: Essential for developing and validating ELISA, Western blot, and other immunoassays targeting amyloid-beta peptides, ensuring specificity and accuracy.
• Biophysical Studies: Employed in structural biology research using techniques like NMR, CD spectroscopy, and electron microscopy to understand peptide conformation and interaction.
• Academic & Pharmaceutical R&D: A fundamental tool for investigating the molecular mechanisms underlying Alzheimer's disease and related dementias.
• Diagnostic Reagent Manufacturing: Used in the production and calibration of diagnostic kits and reagents for detecting amyloid-beta biomarkers.

Basic Information

Product Name	Teplow'S Amyloid β-Protein (1-42) (Scrambled Ii) Trifluoroacetate Salt
CAS No.	1987844-92-7
Molecular Formula	C203H311N55O60S • xC2HF3O2
Molecular Weight	~4514.0 g/mol (free base)
Synonyms	Aβ (1-42) Scrambled Control; Amyloid β-Protein (1-42) Scrambled Sequence; Scrambled Aβ42; Aβ42 Scrambled Peptide; Scrambled Amyloid-β (1-42); DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA (Scrambled); Teplow's Scrambled Aβ1-42 TFA Salt; Synthetic Amyloid β-Peptide (1-42) Scrambled
EINECS	Contact for details

Quality Control

Our Teplow'S Amyloid β-Protein (1-42) (Scrambled Ii) Trifluoroacetate Salt is manufactured under stringent conditions to ensure the highest standards of purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and peptide content. We adhere to quality management principles aligned with GMP guidelines for research chemicals, ensuring traceability and reliability for our global clientele in pharmaceutical and academic research.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. For optimal stability, aliquot into single-use quantities to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 70% (by amino acid analysis)
Molecular Weight (MS)	Conforms to theoretical mass (± 2 Da)
Solubility	Soluble in water or dilute acetic acid
Single Impurity (HPLC)	≤ 1.0%
Trifluoroacetate Content	≤ 15% (by NMR or ion chromatography)
Water Content (KF)	≤ 8.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.