Description

Cyclohexanecarboxylic Acid, 1-[[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino]-4,4-Difluoro- is a high-purity, advanced pharmaceutical intermediate featuring a unique difluorocyclohexyl scaffold protected by a fluorenylmethyloxycarbonyl (Fmoc) group. This compound is specifically engineered for the synthesis of complex bioactive molecules, offering precise stereochemical control and enhanced metabolic stability. It is an essential building block for medicinal chemists and process development scientists in the research and production of novel therapeutic agents, including peptide mimetics and small molecule drugs targeting challenging disease pathways.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs) with incorporated difluorocyclohexyl motifs for improved potency and pharmacokinetic properties.
• Peptidomimetic Drug Discovery: Serves as a key non-natural amino acid analog in the solid-phase and solution-phase synthesis of peptide-based therapeutics and diagnostic agents.
• Protease Inhibitor Development: Used in constructing specialized scaffolds for inhibitors targeting proteolytic enzymes, leveraging the conformational restraint of the cyclohexane ring.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme mechanisms and protein-protein interactions in biological systems.
• Agrochemical Research: Potential intermediate for developing novel agrochemicals where the difluoro group can influence biological activity and environmental stability.
• Material Science: Can be utilized in the synthesis of specialized monomers for advanced polymers with specific thermal or chemical resistance properties.

Basic Information

Product Name	Cyclohexanecarboxylic Acid, 1-[[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino]-4,4-Difluoro-
CAS No.	1986905-26-3
Molecular Formula	C22H21F2NO4
Molecular Weight	401.41 g/mol
Synonyms	1-Fmoc-amino-4,4-difluorocyclohexanecarboxylic acid; 4,4-Difluoro-1-[(9H-fluoren-9-ylmethoxy)carbonylamino]cyclohexanecarboxylic acid; Fmoc-4,4-difluorocyclohexylglycine; Fmoc-Difluorocyclohexylgly-OH; (4,4-Difluorocyclohexyl)-N-Fmoc-glycine; 1-[(Fmoc)amino]-4,4-difluorocyclohexane-1-carboxylic acid; 4,4-Difluoro-1-(Fmoc-amino)cyclohexanecarboxylic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4,4-difluorocyclohexylglycine
EINECS	Contact for details

Quality Control

Our Cyclohexanecarboxylic Acid, 1-[[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino]-4,4-Difluoro- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural integrity suitable for sensitive pharmaceutical applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions or an inert atmosphere to maintain stability. For long-term storage, consider storing desiccated at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.