Description

1,2-Pyrrolidinedicarboxylic Acid, 3,3-Dimethyl-, 1-(9H-Fluoren-9-Ylmethyl) Ester, (2S)- is a high-purity, chiral building block of significant interest in advanced organic synthesis. This compound is valued for its role as a protected amino acid derivative, enabling the precise construction of complex molecular architectures. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), peptide mimetics, and other fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new therapeutic agents and active pharmaceutical ingredients (APIs).
• Peptide Chemistry: Serves as a protected amino acid derivative for the solid-phase and solution-phase synthesis of complex peptides and peptidomimetics.
• Asymmetric Synthesis: Used as a building block to introduce stereochemical complexity in catalytic and stoichiometric asymmetric transformations.
• Protecting Group Strategy: The 9-fluorenylmethyl (Fm) ester moiety is utilized for temporary carboxylate protection in multi-step synthetic sequences.
• Chemical Biology Research: Employed in the design and synthesis of molecular probes, enzyme inhibitors, and other biologically active compounds.
• Process Chemistry Development: Investigated for scalable routes in the production of high-value fine chemicals and advanced intermediates.

Basic Information

Product Name	1,2-Pyrrolidinedicarboxylic Acid, 3,3-Dimethyl-, 1-(9H-Fluoren-9-Ylmethyl) Ester, (2S)-
CAS No.	1982344-79-5
Molecular Formula	C23H23NO4
Molecular Weight	377.44 g/mol
Synonyms	(2S)-1-(9H-Fluoren-9-ylmethyl) 3,3-dimethylpyrrolidine-1,2-dicarboxylate; Fmoc-3,3-Dimethyl-D-proline; Fmoc-D-3,3-Dimethylproline; Fmoc-3,3-Dimethyl-D-pro-OH; 1-(9H-Fluoren-9-ylmethyl) (2S)-3,3-dimethylpyrrolidine-1,2-dicarboxylate; N-α-Fmoc-3,3-dimethyl-D-proline; (S)-1-((((9H-Fluoren-9-yl)methoxy)carbonyl)-3,3-dimethylpyrrolidine-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We provide Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Quality is assured through analytical techniques including HPLC, NMR, and mass spectrometry. Specifications are designed to meet the stringent requirements of pharmaceutical R&D and process chemistry.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Optical Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.