Description

(2S)-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}(Methyl)Amino)-4-Methoxybutanoic Acid is a sophisticated, optically pure Fmoc-protected amino acid derivative designed for advanced synthetic applications. This compound is critical for constructing complex peptide sequences where precise stereochemistry and side-chain functionality are paramount. It is an essential building block for researchers and manufacturers in pharmaceutical development, particularly in the synthesis of peptide-based therapeutics and novel drug candidates.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the automated, sequential assembly of peptides on resin, leveraging the Fmoc protecting group strategy.
• Pharmaceutical Intermediates: Serves as a crucial intermediate in the research and development of new active pharmaceutical ingredients (APIs), especially for metabolic and oncological targets.
• Peptidomimetic Design: Used to introduce the 4-methoxybutanoic acid side chain into synthetic peptides to modulate bioavailability, stability, and receptor binding affinity.
• Bioconjugation and Labeling: The carboxylic acid moiety allows for further functionalization, enabling the creation of peptide-drug conjugates or fluorescently labeled probes for diagnostic applications.
• Academic and Industrial Research: A valuable reagent for chemical biology studies exploring protein-protein interactions and enzyme mechanisms.

Basic Information

Product Name	(2S)-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}(Methyl)Amino)-4-Methoxybutanoic Acid
CAS No.	1979169-11-3
Molecular Formula	C21H23NO6
Molecular Weight	385.41 g/mol
Synonyms	Fmoc-N-Me-4-methoxy-L-homoglutamic acid; Fmoc-N-methyl-4-methoxy-L-homoglutamic acid; (2S)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl](methyl)amino]-4-methoxybutanoic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-4-methoxy-L-homoglutamic acid; Fmoc-N-Me-4-OMe-L-hGlu-OH; Nα-Fmoc-Nα-methyl-4-methoxy-L-homoglutamic acid
EINECS	Contact for details

Quality Control

Our production of (2S)-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}(Methyl)Amino)-4-Methoxybutanoic Acid adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for sensitive applications. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry. Certificates of Analysis (COA) detailing identity, purity (typically ≥95% by HPLC), chiral purity, and impurity profiles are provided with every shipment to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive); containers should be allowed to reach ambient temperature before opening to minimize condensation and moisture uptake. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Chiral Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.