Description

Ald-Benzyl-Amide-Peg4-Propargyl (CAS NO 1969299-27-1) is a specialized heterobifunctional polyethylene glycol (PEG) linker featuring a benzyl-protected aldehyde group and a terminal propargyl group. This compound is engineered to facilitate controlled bioconjugation and the synthesis of complex molecular architectures, offering precise control over reaction sites and spacing. It is an essential reagent for researchers and manufacturers in pharmaceutical development, bioconjugation, and advanced materials science, particularly for creating antibody-drug conjugates (ADCs), PEGylated therapeutics, and functionalized surfaces.

Application

• Bioconjugation and ADC Development: A key building block for site-specific conjugation of cytotoxic drugs to antibodies or proteins via orthogonal click chemistry and aldehyde coupling strategies.
• PEGylation Reagent: Used to introduce hydrophilic PEG spacers onto drug molecules or surfaces, improving solubility, stability, and pharmacokinetic profiles.
• Click Chemistry Scaffold: The terminal propargyl group enables efficient copper-catalyzed azide-alkyne cycloaddition (CuAAC) for labeling, crosslinking, and polymer synthesis.
• Surface Functionalization: Employed to modify nanoparticles, biosensors, and chromatographic media with aldehyde handles for subsequent immobilization of biomolecules.
• Protecting Group Strategy: The benzyl-protected aldehyde allows for selective deprotection, enabling sequential and controlled multi-step synthetic pathways.
• Crosslinking Agent: Serves as a heterobifunctional crosslinker for creating hydrogels, polymer networks, and biomaterial matrices with tailored properties.

Basic Information

Product Name	Ald-Benzyl-Amide-Peg4-Propargyl
CAS No.	1969299-27-1
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Propargyl-PEG4-CH2-CH2-NH-CO-Ph-CH2-O-CHO (Benzyl protected); Benzyloxy-PEG4-Propargyl Amide Aldehyde; 4,7,10,13-Tetraoxa-16-azahenicos-20-yn-1-al, 17-(phenylmethoxy)-; Heterobifunctional PEG linker aldehyde-propargyl; Benzyl-protected Aldehyde-PEG4-Propargyl; Propargyl-PEG4-Benzyloxyacetaldehyde; ADC/PEGylation Linker 1969299-27-1
EINECS	Contact for details

Quality Control

Our Ald-Benzyl-Amide-Peg4-Propargyl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development and cGMP-grade production to meet the stringent requirements of pharmaceutical and diagnostic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid or viscous liquid
Identification (HPLC/MS)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.