Description

(S)-Pramipexole-D5 Dihydrochloride CAS NO 1965329-42-3 is a high-purity, deuterium-labeled internal standard critical for ensuring the accuracy and reliability of quantitative bioanalytical methods. This compound is indispensable for pharmacokinetic and metabolism studies, providing unmatched precision in mass spectrometry-based assays. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and quality control units requiring definitive analytical standards for the quantification of pramipexole.

Application

• Primary use as an internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS/MS) for the bioanalysis of pramipexole in biological matrices (plasma, serum, urine).
• Essential for conducting pharmacokinetic (PK) and pharmacodynamic (PD) studies during drug development and clinical trials.
• Enables precise drug metabolism and excretion studies, facilitating metabolite identification and profiling.
• Supports therapeutic drug monitoring (TDM) and bioequivalence studies for generic drug applications.
• Used in quality control and method validation within analytical laboratories to ensure regulatory compliance (e.g., FDA, EMA).
• Critical for research into Parkinson's disease therapeutics, aiding in the accurate quantification of drug concentrations in preclinical and clinical samples.

Basic Information

Product Name	(S)-Pramipexole-D5 Dihydrochloride
CAS No.	1965329-42-3
Molecular Formula	C10H12D5N3S • 2HCl
Molecular Weight	302.28 g/mol (approx.)
Synonyms	(6S)-6-N-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine-D5 dihydrochloride; Pramipexole D5 dihydrochloride; SND-919-D5 dihydrochloride; Mirapex-D5 dihydrochloride; (S)-2-Amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole-D5 dihydrochloride; (S)-Pramipexole D5 2HCl; Deuterated Pramipexole Dihydrochloride Internal Standard
EINECS	Contact for details

Quality Control

Every batch of (S)-Pramipexole-D5 Dihydrochloride is manufactured and analyzed under strict quality systems. We guarantee high chemical and isotopic purity suitable for sensitive analytical applications. Comprehensive testing includes assay, isotopic enrichment, and impurity profiling via advanced techniques like HPLC and NMR. A detailed Certificate of Analysis (COA) is provided with each shipment, ensuring traceability and compliance with relevant industry standards.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. Due to its hygroscopic nature, the product should be handled in a dry environment and desiccated upon opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D5)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.