Description

Thalidomide-o-C6-Nh2 Tfa is a high-purity, functionalized thalidomide derivative designed for advanced pharmaceutical research and development. This compound serves as a critical intermediate or building block for the synthesis of novel targeted protein degraders, such as Proteolysis-Targeting Chimeras (PROTACs). It is essential for medicinal chemists and research institutions focused on oncology, immunology, and neurodegenerative disease research, where precise molecular modification is required to develop next-generation therapeutic agents.

Application

• PROTAC Linker Synthesis: A key chemical component for constructing the linker moiety that connects an E3 ligase ligand to a protein-of-interest (POI) ligand in PROTAC molecules.
• Bioconjugation & Probe Development: Used to create chemical probes for studying cereblon (CRBN) E3 ubiquitin ligase engagement and substrate degradation pathways.
• Medicinal Chemistry Research: Serves as a versatile intermediate for the structural optimization of immunomodulatory imide drug (IMiD) analogs and molecular glues.
• Preclinical Drug Candidate Development: Integral to the discovery phase for novel targeted therapies in academic, biotech, and pharmaceutical R&D laboratories.

Basic Information

Product Name	Thalidomide-o-C6-Nh2 Tfa
CAS No.	1957235-99-2
Molecular Formula	C₂₀H₂₀F₃N₃O₇
Molecular Weight	471.39 g/mol
Synonyms	2-(2,6-Dioxopiperidin-3-yl)-4-((6-((2,2,2-trifluoroacetamido)hexyl)oxy)isoindoline-1,3-dione; (3aR,7aS)-2-(6-((2,2,2-Trifluoroacetamido)hexyl)oxy)-1,3-dioxo-2,3,3a,4,7,7a-hexahydro-1H-isoindol-4-yl)piperidine-2,6-dione; Thalidomide-C6-NH2 TFA; Thalidomide-PEG6-NH2 TFA; Thalidomide-PEG6-amine TFA salt; PROTAC Linker Thalidomide derivative; CRBN Ligand-Linker Conjugate
EINECS	Contact for details

Quality Control

Our Thalidomide-o-C6-Nh2 Tfa is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed chromatographic data are provided to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.