Description

(R)-tert-Butyl 2-Oxo-6-Phenylpiperidine-1-Carboxylate is a high-value chiral building block and synthetic intermediate of significant interest in advanced organic synthesis. Its core value lies in its well-defined stereochemistry and protected amine functionality, which are critical for constructing complex, biologically active molecules with high enantiomeric purity. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of novel active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel therapeutic agents, including central nervous system (CNS) drugs and enzyme inhibitors.
• Asymmetric Synthesis: Serves as a versatile precursor for constructing complex piperidine-based scaffolds with defined (R)-configuration in stereoselective reactions.
• Agrochemical Research: Used in the development of new chiral pesticides and herbicides where specific stereochemistry impacts biological activity.
• Catalyst and Ligand Development: Acts as a starting material for synthesizing novel chiral catalysts and ligands used in homogeneous catalysis.
• Academic & Contract Research: Employed in university and CRO laboratories for methodological studies in organic and medicinal chemistry.
• Custom Synthesis: A foundational component for custom manufacturing and scale-up projects requiring high-purity, enantiomerically enriched intermediates.

Basic Information

Product Name	(R)-tert-Butyl 2-Oxo-6-Phenylpiperidine-1-Carboxylate
CAS No.	1956436-99-9
Molecular Formula	C16H21NO3
Molecular Weight	275.34 g/mol
Synonyms	1-Boc-6-phenyl-2-piperidinone (R-enantiomer); (R)-1-(tert-Butoxycarbonyl)-6-phenylpiperidin-2-one; tert-Butyl (R)-2-oxo-6-phenylpiperidine-1-carboxylate; (R)-N-Boc-6-phenyl-2-piperidone; (R)-6-Phenyl-2-piperidinone-1-carboxylic acid tert-butyl ester; Boc-(R)-6-phenyl-2-piperidone; (R)-1-Boc-6-phenyl-δ²-piperidone
EINECS	Contact for details

Quality Control

Our (R)-tert-Butyl 2-Oxo-6-Phenylpiperidine-1-Carboxylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity. Each lot undergoes comprehensive analytical testing, including chiral HPLC to confirm enantiomeric excess (ee) and standard purity assays. A detailed Certificate of Analysis (COA) documenting identity, purity, and chiral purity is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound may be moisture-sensitive; keep the container tightly sealed under an inert atmosphere for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.