Description

Endo-Bcn-Peg2-Alcohol is a specialized bifunctional polyethylene glycol (PEG) linker featuring an endo-BCN (bicyclo[6.1.0]nonyne) group and a terminal alcohol. This compound is engineered for high-efficiency, copper-free click chemistry applications, enabling rapid and bioorthogonal conjugation under mild physiological conditions. It is an essential building block for researchers and manufacturers in bioconjugation, pharmaceutical development, and advanced materials science, where precise and stable molecular assembly is critical.

Application

• Bioconjugation and Antibody-Drug Conjugate (ADC) Development: Used as a linker to attach cytotoxic payloads, fluorescent dyes, or other functional molecules to antibodies, proteins, or peptides.
• Proteomics and Biomarker Discovery: Facilitates the labeling and enrichment of biomolecules for mass spectrometry analysis and cellular imaging studies.
• Polymer and Hydrogel Synthesis: Serves as a cross-linking agent or functional monomer to create smart materials with tailored properties for drug delivery or tissue engineering.
• Diagnostic Reagent Formulation: Employed in the development of diagnostic assays and imaging probes due to its fast reaction kinetics with azide-tagged molecules.
• Surface Functionalization: Used to modify nanoparticles, chips, or other solid supports with bioactive ligands for biosensor and microarray applications.
• Chemical Biology Tool Development: A key reagent for studying biological processes in live cells through bioorthogonal labeling strategies.

Basic Information

Product Name	Endo-Bcn-Peg2-Alcohol
CAS No.	1951439-51-2
Molecular Formula	C₁₆H₂₇NO₄
Molecular Weight	297.39 g/mol
Synonyms	endo-BCN-PEG2-OH; (1R,8S,9s)-Bicyclo[6.1.0]non-4-yn-9-ylmethyl 2-[2-(2-hydroxyethoxy)ethoxy]acetate; 2-[2-(2-{[(1R,8S,9s)-Bicyclo[6.1.0]non-4-yn-9-yl]methoxy}-2-oxoethoxy)ethoxy]ethan-1-ol; BCN-PEG2-Alcohol; endo-BCN-PEG2-CH2CH2OH
EINECS	Contact for details

Quality Control

Our Endo-Bcn-Peg2-Alcohol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent performance for sensitive research and development applications. Certificates of Analysis (COA) with detailed specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C. Allow the product to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.