Description

Methyl Rel-(1R,3S)-3-{[(tert-Butoxy)Carbonyl]Amino}-1-Methylcyclobutane-1-Carboxylate CAS NO 1946010-92-9 is a high-purity, stereochemically defined cyclobutane derivative, serving as a critical chiral building block in advanced organic synthesis. Its value lies in providing a rigid, functionalized scaffold that is essential for constructing complex molecular architectures with precise three-dimensional control. This compound is primarily needed by pharmaceutical R&D and process chemistry teams for the development of novel active pharmaceutical ingredients (APIs), particularly in areas targeting central nervous system (CNS) disorders and metabolic diseases.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of novel drug candidates, especially for neurological and psychiatric targets.
• Peptidomimetic Chemistry: Used to introduce constrained, non-natural amino acid motifs into peptide backbones to enhance metabolic stability and receptor selectivity.
• Medicinal Chemistry SAR Studies: Employed to explore structure-activity relationships by systematically modifying the cyclobutane core in lead optimization programs.
• Asymmetric Synthesis: Serves as a starting material or intermediate in catalytic asymmetric transformations to access enantiomerically pure compounds.
• Protease Inhibitor Development: The Boc-protected amino acid ester functionality makes it relevant for designing inhibitors of specific enzyme classes like proteases.
• Chemical Biology Probe Synthesis: Utilized in the construction of molecular probes for studying biological pathways and protein function.

Basic Information

Product Name	Methyl Rel-(1R,3S)-3-{[(tert-Butoxy)Carbonyl]Amino}-1-Methylcyclobutane-1-Carboxylate
CAS No.	1946010-92-9
Molecular Formula	C13H23NO4
Molecular Weight	257.33 g/mol
Synonyms	Methyl (1R,3S)-3-[(tert-Butoxycarbonyl)amino]-1-methylcyclobutane-1-carboxylate; Methyl 3-[(tert-Butoxycarbonyl)amino]-1-methylcyclobutane-1-carboxylate; (1R,3S)-Methyl 3-(Boc-amino)-1-methylcyclobutane-1-carboxylate; rel-(1R,3S)-Methyl 3-((tert-butoxycarbonyl)amino)-1-methylcyclobutane-1-carboxylate; Boc-ACMC-OMe; 1-Methylcyclobutane-1-carboxylic acid, 3-[(1,1-dimethylethoxy)carbonyl]amino-, methyl ester, (1R,3S)-rel-; Methyl 1-methyl-3-[(tert-butoxycarbonyl)amino]cyclobutane-1-carboxylate
EINECS	Contact for details

Quality Control

Our production of Methyl Rel-(1R,3S)-3-{[(tert-Butoxy)Carbonyl]Amino}-1-Methylcyclobutane-1-Carboxylate adheres to stringent quality protocols suitable for pharmaceutical R&D applications. Every batch undergoes comprehensive analytical characterization, including chiral purity verification, to ensure consistent identity, purity, and stereochemical integrity. Certificates of Analysis (COA) detailing results from HPLC, NMR, and optical rotation tests are provided to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.