Description

3-Chloro-2-(Trifluoromethoxy)Phenylboronic Acid is a high-value organoboron building block, specifically a functionalized phenylboronic acid derivative. Its core value proposition lies in enabling the precise synthesis of complex molecules via cross-coupling reactions, such as the Suzuki-Miyaura reaction, which is fundamental to modern pharmaceutical and agrochemical research. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries who require a reliable, high-purity intermediate for constructing novel chemical entities.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and infectious diseases.
• Agrochemical Research: Used to create novel herbicides, fungicides, and insecticides by incorporating the trifluoromethoxy and chloro substituents, which can enhance biological activity and metabolic stability.
• Ligand & Catalyst Development: Serves as a precursor for synthesizing specialized ligands used in asymmetric catalysis and transition metal complexes.
• Material Science: Employed in the development of organic electronic materials, such as OLEDs and semiconductors, where the boronic acid group facilitates polymerization or functionalization.
• Chemical Biology & Probe Synthesis: Utilized to create molecular probes and sensors for studying biological processes, leveraging the boronic acid's affinity for diols.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences market.

Basic Information

Product Name	3-Chloro-2-(Trifluoromethoxy)Phenylboronic Acid
CAS No.	1942072-67-4
Molecular Formula	C7H5BClF3O3
Molecular Weight	239.37 g/mol
Synonyms	[3-Chloro-2-(trifluoromethoxy)phenyl]boronic acid; 2-Chloro-6-(trifluoromethoxy)benzeneboronic acid; (3-Chloro-2-(trifluoromethoxy)phenyl)boronic acid; Boronic acid, B-[3-chloro-2-(trifluoromethoxy)phenyl]-; 3-Chloro-2-trifluoromethoxybenzeneboronic acid; 3-Chloro-2-(trifluoromethoxy)benzeneboronic acid; 2-(Trifluoromethoxy)-3-chlorophenylboronic acid
EINECS	Contact for details

Quality Control

Our 3-Chloro-2-(Trifluoromethoxy)Phenylboronic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and batch-to-batch consistency suitable for sensitive cross-coupling reactions. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment. We support compliance with REACH and other global regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.