Description

Dspe-Peg(5000) Azide CAS NO 1938081-40-3 is a heterobifunctional polyethylene glycol (PEG) derivative featuring a distearoylphosphatidylethanolamine (DSPE) lipid anchor and a terminal azide group. This compound is a critical building block in bioconjugation and nanotechnology, enabling the site-specific modification of biomolecules and surfaces via click chemistry. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors for applications such as drug delivery system development, liposome functionalization, and surface engineering.

Application

• Liposome and Nanoparticle Functionalization: Acts as a key component for incorporating stealth properties (PEGylation) and reactive azide handles into lipid-based drug delivery carriers for targeted therapies.
• Bioconjugation and Click Chemistry: The terminal azide group enables efficient, copper-catalyzed or strain-promoted cycloaddition (SPAAC) with alkyne-modified proteins, antibodies, or other ligands.
• Surface Modification and Immobilization: Used to create functionalized surfaces on chips, sensors, or chromatography media for biosensing and diagnostic applications.
• Synthesis of PEGylated Lipids: Serves as a versatile intermediate for the custom synthesis of various functionalized PEG-lipid conjugates.
• Drug Delivery Research: Facilitates the development of advanced, long-circulating nanomedicines by providing a stable, amphiphilic linker between hydrophobic cores and hydrophilic, functional coronas.
• Biomaterial Engineering: Incorporated into hydrogels or polymer matrices to introduce bio-orthogonal reactivity for cell encapsulation or tissue engineering scaffolds.

Basic Information

Item	Details
Product Name	Dspe-Peg(5000) Azide
CAS No.	1938081-40-3
Molecular Formula	C265H520N6O127P (Approximate)
Molecular Weight	~5000 g/mol (PEG average Mn)
Synonyms	1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[azido(polyethylene glycol)-5000]; DSPE-PEG5000-N3; DSPE-PEG5k-Azide; Azido-PEG5000-DSPE; Phosphoethanolamine-PEG-Azide; N3-PEG5000-DSPE; PEG-DSPE Azide; Lipid-PEG-Azide
EINECS	Contact for details

Quality Control

Our Dspe-Peg(5000) Azide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity, consistent molecular weight distribution, and functional group integrity. Certificates of Analysis (COA) are provided, detailing specifications for critical parameters such as azide content, PEG molecular weight, and lipid purity. We support cGMP-grade production for pharmaceutical development upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture absorption. For long-term storage, keep under an inert atmosphere (argon or nitrogen).

Specification

Item	Specification
Appearance	White to off-white solid or waxy solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥95%
PEG Average Mn (NMR/SEC)	5000 ± 500 Da
Dispersity (Đ)	≤1.05
Azide Content (Functional Assay)	≥90% of theoretical
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.