Description

Benzenamine, 2,3-Difluoro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- is a high-value, multi-functional aromatic amine boronic ester derivative, serving as a critical building block in modern synthetic chemistry. Its core value lies in enabling precise carbon-carbon bond formation via the Suzuki-Miyaura cross-coupling reaction, a cornerstone for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-purity intermediates for drug discovery and specialty chemical synthesis.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for fluorinated drug candidates targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used to create novel herbicides, fungicides, and insecticides with enhanced efficacy and environmental profile through selective coupling reactions.
• Material Science: Building block for organic electronic materials, including organic light-emitting diodes (OLEDs) and semiconductors, where the fluorine and boronate groups tune electronic properties.
• Ligand & Catalyst Development: Serves as a precursor for sophisticated ligands in asymmetric catalysis and transition metal complexes.
• Chemical Biology & Proteomics: Utilized in the development of molecular probes and activity-based protein profiling (ABPP) agents due to its reactive boronate handle.
• Polymer Chemistry: Monomer for synthesizing specialty polymers with unique thermal, mechanical, or optical characteristics.

Basic Information

Product Name	Benzenamine, 2,3-Difluoro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-
CAS No.	1937236-09-3
Molecular Formula	C12H16BF2NO2
Molecular Weight	255.07 g/mol
Synonyms	2,3-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline; 4-Amino-2,3-difluorophenylboronic acid pinacol ester; 2,3-Difluoro-4-(pinacolatoboryl)aniline; (4-Amino-2,3-difluorophenyl)boronic acid pinacol ester; 2,3-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenamine; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-difluoroaniline; 2,3-Difluoro-4-boronoaniline pinacol ester; B-(4-Amino-2,3-difluorophenyl)boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our Benzenamine, 2,3-Difluoro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural integrity suitable for sensitive cross-coupling reactions. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency, meeting the stringent requirements of pharmaceutical R&D and cGMP starting material guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening to prevent decomposition. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.