Description

3-Aminobicyclo[1.1.1]pentane-1-carbonitrile is a high-value, structurally constrained bicyclic amine derivative. This compound matters as a sophisticated building block for medicinal chemistry, enabling the synthesis of novel drug candidates with improved metabolic stability and three-dimensional character. Pharmaceutical R&D and agrochemical innovators need it to explore new chemical space and develop next-generation bioactive molecules.

Application

• Pharmaceutical Intermediate: A key synthon for constructing [1.1.1]propellane-based bioisosteres in drug discovery programs, particularly for replacing tert-butyl or aromatic groups.
• Medicinal Chemistry Research: Used in the synthesis of lead compounds targeting central nervous system (CNS) disorders, inflammatory diseases, and oncology.
• Agrochemical Development: Serves as a precursor for novel active ingredients requiring rigid, three-dimensional scaffolds for enhanced target specificity.
• Chemical Biology Probes: Incorporation into molecular probes and tool compounds for studying enzyme function and protein-protein interactions.
• Advanced Material Synthesis: Potential monomer or cross-linker for creating polymers with unique mechanical properties derived from the strained bicyclic core.
• Peptidomimetics: Enables the design of constrained peptide analogs with improved bioavailability and proteolytic stability.

Basic Information

Product Name	3-Aminobicyclo[1.1.1]pentane-1-carbonitrile
CAS No.	1936643-30-9
Molecular Formula	C7H8N2
Molecular Weight	120.15 g/mol
Synonyms	3-Amino[1.1.1]propellane-1-carbonitrile; 1-Cyano-3-aminobicyclo[1.1.1]pentane; 3-Amino-BCP-CN; Bicyclo[1.1.1]pentane-1-carbonitrile, 3-amino-; 3-Aminobicyclo[1.1.1]pentyl-1-carbonitrile; 1-Cyano-3-azabicyclo[1.1.1]pentane (tautomeric form); Aminopropellane carbonitrile
EINECS	Contact for details

Quality Control

Our 3-Aminobicyclo[1.1.1]pentane-1-carbonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent performance for critical R&D and scale-up applications. Certificates of Analysis (COA) with full analytical data are provided to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) in its original packaging to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.