Description

[S(R)]-n-[(1S)-1-[3',5'-Bis(1,1-Dimethylethyl)-4'-Methoxy[1,1'-Biphenyl]-2-Yl]-2-(Diphenylphosphino)Ethyl]-2-Methyl-2-Propanesulfinamide is a sophisticated chiral sulfinamide-phosphine hybrid ligand, representing a high-value building block in asymmetric synthesis. Its core value lies in enabling precise stereochemical control in transition metal-catalyzed reactions, which is critical for producing enantiomerically pure pharmaceuticals and fine chemicals. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity, specialty ligands to develop novel synthetic routes and optimize catalytic processes.

Application

• As a chiral ligand in asymmetric hydrogenation, hydroformylation, and cross-coupling reactions for pharmaceutical intermediate synthesis.
• Critical component in the development of enantioselective catalysts for the production of active pharmaceutical ingredients (APIs).
• Use in academic and industrial research for exploring new methodologies in organometallic chemistry and catalysis.
• Precursor for the synthesis of more complex, tailor-made phosphine-sulfinamide ligands with specific steric and electronic properties.
• Application in the synthesis of chiral compounds for agrochemicals and flavors & fragrances.
• Tool for process chemistry optimization in scaling up asymmetric transformations from lab to pilot plant.

Basic Information

Product Name	[S(R)]-n-[(1S)-1-[3',5'-Bis(1,1-Dimethylethyl)-4'-Methoxy[1,1'-Biphenyl]-2-Yl]-2-(Diphenylphosphino)Ethyl]-2-Methyl-2-Propanesulfinamide
CAS No.	1936438-26-4
Molecular Formula	C41H52NO2PS
Molecular Weight	653.89 g/mol
Synonyms	(S)-tert-Butanesulfinamide, (R)-2-(Diphenylphosphino)-1-((S)-3,5-di-tert-butyl-4'-methoxy-[1,1'-biphenyl]-2-yl)ethyl Derivative; (S)-N-((1S)-1-(3',5'-Di-tert-butyl-4'-methoxy-[1,1'-biphenyl]-2-yl)-2-(diphenylphosphino)ethyl)-2-methylpropane-2-sulfinamide; Chiral Sulfinamide-Phosphine Ligand; tert-Butylsulfinamide Phosphine Ligand; Biphenyl-based Sulfinyl Phosphine; Asymmetric Synthesis Ligand CAS 1936438-26-4
EINECS	Contact for details

Quality Control

Our production of this high-purity ligand adheres to strict quality protocols to ensure batch-to-batch consistency and optimal catalytic performance. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and chiral analysis to confirm identity, purity, and enantiomeric excess. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support development under cGMP guidelines where required for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C or as specified on the label or COA. This compound is sensitive to oxidation and moisture; ensure containers are sealed properly after each use to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.