Description

[S(R)]-n-[(1S)-1-[3',5'-Bis(1,1-Dimethylethyl)[1,1'-Biphenyl]-2-Yl]-2-(Diphenylphosphino)Ethyl]-2-Methyl-2-Propanesulfinamide is a sophisticated chiral sulfinamide-phosphine hybrid ligand, a key building block in asymmetric synthesis. This compound is critical for enabling high enantioselectivity and yield in catalytic transformations, particularly in the pharmaceutical and fine chemical industries. It is essential for researchers and process chemists developing novel active pharmaceutical ingredients (APIs) and other high-value chiral molecules.

Application

• As a chiral ligand in transition metal-catalyzed asymmetric reactions, such as hydrogenation, cross-coupling, and hydroformylation.
• Critical intermediate in the research and development of novel pharmaceuticals, especially for constructing complex, stereodefined molecular architectures.
• Used in academic and industrial laboratories for method development in asymmetric synthesis.
• Potential application in the synthesis of agrochemicals and other specialty chemicals requiring precise stereochemical control.
• As a scalable building block for GMP and non-GMP production of chiral drug candidates.

Basic Information

Product Name	[S(R)]-n-[(1S)-1-[3',5'-Bis(1,1-Dimethylethyl)[1,1'-Biphenyl]-2-Yl]-2-(Diphenylphosphino)Ethyl]-2-Methyl-2-Propanesulfinamide
CAS No.	1936438-24-2
Molecular Formula	C40H48NOPS
Molecular Weight	621.85 g/mol
Synonyms	(SR)-N-[(1S)-1-[3',5'-Di-tert-butylbiphenyl-2-yl]-2-(diphenylphosphino)ethyl]-2-methylpropane-2-sulfinamide; Chiral Sulfinamide-Phosphine Ligand; tert-Butanesulfinamide Derivative; Asymmetric Synthesis Ligand; Biphenyl-based Chiral Auxiliary; (S)-tert-Butanesulfinamide Phosphine Hybrid; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our production of this advanced chiral intermediate adheres to strict quality protocols to ensure batch-to-batch consistency and high chemical purity. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and chiral analysis to confirm identity, purity, and enantiomeric excess. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support development from research to commercial scale with appropriate documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under an inert atmosphere when appropriate to ensure long-term stability. Keep the container tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.