Description

2,4-Difluoro-5-Iodoanisole is a high-purity, multi-functional halogenated anisole derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring iodine and fluorine substituents on an anisole ring, makes it an exceptionally versatile intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for applications such as cross-coupling reactions and the synthesis of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in the development of fluorine-containing bioactive molecules via Suzuki-Miyaura, Stille, or other palladium-catalyzed cross-coupling reactions.
• Agrochemical Research: Used in the discovery and development of new herbicides, fungicides, and pesticides, where the difluoro and iodo groups can enhance biological activity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a building block for advanced electronic materials, where its halogenated aromatic core contributes to the desired molecular polarity and mesogenic properties.
• Ligand Synthesis: Employed in the preparation of specialized ligands for catalysis, leveraging the iodine atom for further functionalization to create complex chelating structures.
• Chemical Biology Probes: Useful for synthesizing tagged molecules or probes for studying biological systems, as the iodine handle allows for radiolabeling or further bioconjugation.

Basic Information

Item	Detail
Product Name	2,4-Difluoro-5-Iodoanisole
CAS No.	1936250-49-5
Molecular Formula	C7H5F2IO
Molecular Weight	269.02 g/mol
Synonyms	5-Iodo-2,4-difluoroanisole; 1-Iodo-2,4-difluoro-5-methoxybenzene; 2,4-Difluoro-1-iodo-5-methoxybenzene; 2,4-Difluoro-5-methoxyiodobenzene; Benzene, 1-iodo-2,4-difluoro-5-methoxy-; 5-Methoxy-2,4-difluoro-1-iodobenzene
EINECS	Contact for details

Quality Control

Our 2,4-Difluoro-5-Iodoanisole is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, assay, and impurity profiles. We adhere to cGMP principles where applicable to support our clients in regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and packaging should minimize exposure to direct light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Assay (GC)	≥96.0%
Melting Point	Contact for details
Heavy Metals	<20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.