Description

3-Hydroxyoxetane-3-Carbonitrile is a versatile and high-value oxetane-based building block, distinguished by its unique combination of a strained oxetane ring and a nitrile functional group. This molecular architecture makes it a critical intermediate for the synthesis of complex pharmaceuticals, agrochemicals, and advanced materials, enabling the introduction of both polarity and three-dimensionality into target molecules. It is particularly sought after by R&D chemists and process development scientists in the pharmaceutical and fine chemical industries for constructing novel molecular scaffolds and developing new synthetic routes.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), especially in medicinal chemistry programs targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the oxetane moiety can enhance metabolic stability and bioavailability.
• Polymer & Material Science: Serves as a monomer or cross-linking agent for creating specialty polymers with tailored properties such as improved adhesion, thermal stability, or optical characteristics.
• Ligand & Catalyst Development: Employed in the synthesis of novel chiral ligands and organocatalysts for asymmetric synthesis applications.
• Chemical Biology Probes: Utilized as a building block for creating molecular probes and tags to study biological processes and protein interactions.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis projects and scale-up services for specialized chemical entities.

Basic Information

Product Name	3-Hydroxyoxetane-3-Carbonitrile
CAS No.	1935287-40-3
Molecular Formula	C4H5NO2
Molecular Weight	99.09 g/mol
Synonyms	3-Hydroxyoxetane-3-carbonitrile; 3-Oxetanecarbonitrile, 3-hydroxy-; 3-Hydroxy-3-oxetanecarbonitrile; 3-Cyano-3-hydroxyoxetane; Oxetan-3-ol, 3-cyano-; 3-Hydroxyoxetane-3-carbonitrile (CAS 1935287-40-3)
EINECS	Contact for details

Quality Control

Every batch of 3-Hydroxyoxetane-3-Carbonitrile is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure consistency and high purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, supporting its use in regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) in its original packaging to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.