Description

[3,3-Difluoro-1-(Hydroxymethyl)Cyclobutyl]Methanol is a versatile and high-value fluorinated cyclobutane derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring a difluorinated cyclobutane ring and dual hydroxymethyl groups, makes it an essential precursor for creating complex molecules with tailored properties. This compound is particularly valuable for research and development chemists in the pharmaceutical and agrochemical industries, where it is used to introduce conformational rigidity and modulate lipophilicity and metabolic stability in target molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), especially in protease inhibitors, kinase inhibitors, and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorinated cyclobutane core can enhance biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated components in electronic display materials, contributing to improved dielectric anisotropy and thermal stability.
• Polymer & Material Science: Acts as a monomer or cross-linking agent for synthesizing specialty polymers with unique surface properties, chemical resistance, or low dielectric constants.
• Fluorine Chemistry Research: An important reagent for exploring new C-F bond formation reactions and studying the stereoelectronic effects of the gem-difluoro group on a strained ring system.
• Peptidomimetics & Bioisosteres: The difluorocyclobutane moiety is used as a bioisostere for carbonyl or other functional groups in drug design to improve pharmacokinetic profiles.

Basic Information

Item	Details
Product Name	[3,3-Difluoro-1-(Hydroxymethyl)Cyclobutyl]Methanol
CAS No.	1934699-78-1
Molecular Formula	C6H10F2O2
Molecular Weight	152.14 g/mol
Synonyms	1,1-Bis(hydroxymethyl)-3,3-difluorocyclobutane; 3,3-Difluorocyclobutane-1,1-dimethanol; (3,3-Difluorocyclobutane-1,1-diyl)dimethanol; 3,3-Difluoro-1,1-bis(hydroxymethyl)cyclobutane; DFCDM; 1,1-Di(hydroxymethyl)-3,3-difluorocyclobutane
EINECS	Contact for details

Quality Control

Our [3,3-Difluoro-1-(Hydroxymethyl)Cyclobutyl]Methanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and commercial synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment. We support cGMP compliance for pharmaceutical applications and can tailor specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and potential degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.