Description

trans-2-(Trifluoromethyl)Cyclopropanecarboxylic Acid CAS NO 1933771-66-4 is a high-value, fluorinated cyclopropane derivative characterized by its unique three-membered ring structure and a potent trifluoromethyl group. This compound is a critical chiral building block and intermediate in advanced organic synthesis, prized for its ability to impart metabolic stability and modulate lipophilicity in target molecules. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, anti-infectives, and metabolic diseases.
• Agrochemical Synthesis: Used in the creation of advanced pesticides and herbicides, where the cyclopropane and trifluoromethyl motifs enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for designing novel ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Investigated as a monomer or additive for creating specialty polymers with unique surface properties and chemical resistance.
• Fluorine Chemistry: An essential reagent for introducing the trifluoromethyl-cyclopropyl moiety into complex molecular architectures.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research organizations for bespoke synthesis projects requiring high-purity, specialized intermediates.

Basic Information

Product Name	trans-2-(Trifluoromethyl)Cyclopropanecarboxylic Acid
CAS No.	1933771-66-4
Molecular Formula	C5H5F3O2
Molecular Weight	154.09 g/mol
Synonyms	(1R,2S)-2-(Trifluoromethyl)cyclopropanecarboxylic Acid; (1S,2R)-2-(Trifluoromethyl)cyclopropanecarboxylic Acid; trans-2-(Trifluoromethyl)cyclopropanecarboxylic acid; rel-(1R,2S)-2-(Trifluoromethyl)cyclopropanecarboxylic Acid; 2-(Trifluoromethyl)cyclopropanecarboxylic Acid, trans-; Cyclopropanecarboxylic acid, 2-(trifluoromethyl)-, trans-; 1933771-66-4
EINECS	Contact for details

Quality Control

Every batch of trans-2-(Trifluoromethyl)Cyclopropanecarboxylic Acid is manufactured under strict quality management systems. We provide comprehensive analytical documentation to ensure traceability and compliance with your project requirements. Certificates of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles are available for each lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong bases and oxidizing agents. For long-term storage, temperatures between 2°C and 8°C are recommended to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.