Description

(1R,3R)-3-(Fmoc-Amino)Cyclohexanecarboxylic Acid is a high-purity, stereochemically defined building block designed for advanced organic synthesis. This compound is critical for the controlled introduction of a protected amino acid moiety into complex molecular architectures, ensuring precise structural outcomes. It is an essential reagent for researchers and manufacturers in pharmaceutical development, particularly in solid-phase peptide synthesis (SPPS) and the creation of peptide mimetics and constrained analogs.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key Fmoc-protected amino acid derivative for the automated, sequential assembly of peptides.
• Pharmaceutical Intermediates: Serves as a crucial chiral building block in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates.
• Peptidomimetics & Conformationally Restricted Peptides: Used to incorporate the cyclohexane scaffold, enhancing metabolic stability and bioavailability of therapeutic peptides.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening to discover new bioactive compounds.
• Bioconjugation & Probe Development: Facilitates the site-specific labeling of peptides and proteins for diagnostic and research applications.
• Academic & Industrial R&D: A fundamental reagent for synthetic chemistry research focused on novel amino acid derivatives and peptide-based materials.

Basic Information

Product Name	(1R,3R)-3-(Fmoc-Amino)Cyclohexanecarboxylic Acid
CAS No.	1932784-63-8
Molecular Formula	C22H23NO4
Molecular Weight	365.42 g/mol
Synonyms	Fmoc-(1R,3R)-3-Aminocyclohexanecarboxylic Acid; (1R,3R)-3-[(9H-Fluoren-9-ylmethoxy)carbonylamino]cyclohexanecarboxylic Acid; Fmoc-3-Acc-OH (1R,3R); (1R,3R)-3-(Fmoc-amino)cyclohexane-1-carboxylic acid; trans-Fmoc-3-aminocyclohexanecarboxylic acid; Fmoc-trans-3-Acc-OH; Fmoc-3-Amino-trans-cyclohexanecarboxylic Acid
EINECS	Contact for details

Quality Control

Our (1R,3R)-3-(Fmoc-Amino)Cyclohexanecarboxylic Acid is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for demanding research and cGMP applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. We adhere to stringent in-house specifications aligned with industry standards for peptide synthesis building blocks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.