Description

D-Alanine, n-[(1,1-Dimethylethoxy)Carbonyl]-3,3,3-Trifluoro- CAS NO 1932644-89-7 is a high-purity, non-natural amino acid derivative featuring a Boc-protected amine and a trifluoromethyl group. This compound is a critical chiral building block designed for advanced pharmaceutical research and development, offering precise stereochemistry and enhanced metabolic stability. It is primarily utilized by medicinal chemists and process development scientists in the synthesis of novel peptide-based therapeutics, enzyme inhibitors, and other bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for metabolic diseases and oncology.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to incorporate a non-natural, trifluoromethylated D-alanine residue, modifying peptide stability and binding properties.
• Protease & Enzyme Inhibitor Development: Serves as a core structural element in designing potent inhibitors for various enzymes, leveraging the electron-withdrawing and steric properties of the trifluoromethyl group.
• Chemical Biology & Probe Design: Employed in creating labeled probes and activity-based protein profiling (ABPP) agents to study biological pathways and target engagement.
• Agrochemical Research: Acts as a precursor in the synthesis of novel herbicides or pesticides with improved environmental persistence and efficacy.
• Material Science: Potential monomer for developing specialized fluorinated polymers with unique surface properties and chemical resistance.

Basic Information

Product Name	D-Alanine, n-[(1,1-Dimethylethoxy)Carbonyl]-3,3,3-Trifluoro- CAS NO 1932644-89-7
CAS No.	1932644-89-7
Molecular Formula	C9H14F3NO4
Molecular Weight	257.21 g/mol
Synonyms	Boc-D-3,3,3-Trifluoroalanine; N-Boc-3,3,3-Trifluoro-D-alanine; (2R)-2-[[(2-Methylpropan-2-yl)oxycarbonyl]amino]-3,3,3-trifluoropropanoic acid;
EINECS	Contact for details

Quality Control

Our D-Alanine, n-[(1,1-Dimethylethoxy)Carbonyl]-3,3,3-Trifluoro- is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the exacting standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.