Description

(S)-2-(Fmoc-Amino)-4-Iodobutanoic Acid is a high-purity, non-natural amino acid derivative designed for advanced peptide synthesis and medicinal chemistry research. This compound serves as a critical chiral building block, enabling the site-specific introduction of iodine atoms and protected amine functionalities into complex molecular architectures. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and agrochemical sectors developing novel peptide-based therapeutics, diagnostic probes, and chemical biology tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled incorporation of iodine-labeled or modified amino acid residues into peptide chains.
• Medicinal Chemistry & Drug Discovery: Used in the synthesis of peptide mimetics and constrained analogs for structure-activity relationship (SAR) studies and lead optimization.
• Chemical Biology & Bioconjugation: Facilitates the synthesis of peptide probes, tags, and linkers for studying protein-protein interactions and cellular processes.
• Radiopharmaceutical Precursors: Acts as a precursor for compounds where the iodine atom can be exchanged for radioactive isotopes (e.g., I-125, I-131) for diagnostic imaging or targeted radiotherapy.
• Agrochemical Research: Employed in the development of novel bioactive peptides and peptidomimetics for crop protection.
• Academic & Institutional Research: A valuable reagent for methodology development in organic synthesis and asymmetric catalysis.

Basic Information

Product Name	(S)-2-(Fmoc-Amino)-4-Iodobutanoic Acid
CAS No.	1932598-55-4
Molecular Formula	C19H18INO4
Molecular Weight	451.16 g/mol
Synonyms	Fmoc-Asp(OBzl)-OH; Fmoc-L-Aspartic acid 4-benzyl ester; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-aspartic acid 4-benzyl ester; (2S)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]butanedioic acid 4-benzyl ester; Fmoc-Asp-OBzl; Fmoc-L-Asp(OBzl)-OH; N-Fmoc-L-aspartic acid β-benzyl ester; L-Aspartic acid, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, 4-benzyl ester
EINECS	Contact for details

Quality Control

Our (S)-2-(Fmoc-Amino)-4-Iodobutanoic Acid is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity suitable for sensitive research and development applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as chiral purity, chemical assay, and impurity profiles. Our quality management system supports compliance with relevant standards for research-grade and cGMP starting materials.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a cool, dry, and well-ventilated place. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.