Description

(2R,5S)-Thiolane-2,5-Dicarboxamide CAS NO 1932206-73-9 is a high-purity, stereochemically defined chiral building block featuring a thiolane (tetrahydrothiophene) ring system. This compound is of significant value in pharmaceutical research and development, serving as a key intermediate for the synthesis of novel active pharmaceutical ingredients (APIs) and complex molecules. It is primarily sought after by research institutions, pharmaceutical companies, and fine chemical manufacturers engaged in drug discovery, particularly for projects involving peptidomimetics, enzyme inhibitors, and other bioactive compounds where specific stereochemistry is critical for efficacy.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for constructing complex drug candidates, especially in oncology, antiviral, and neurological disorder research.
• Peptidomimetic Scaffold: Used to design and synthesize molecules that mimic peptide structures, enhancing metabolic stability and bioavailability.
• Ligand Synthesis: Serves as a precursor for chiral ligands used in asymmetric catalysis to create other enantiomerically pure compounds.
• Bioconjugation Chemistry: The amide and thiolane functionalities can be utilized for linking biomolecules or creating targeted drug delivery systems.
• Material Science Research: Potential building block for advanced polymers or functional materials with specific stereochemical properties.
• Chemical Biology Probes: Used in the development of molecular probes to study enzyme function and biological pathways.

Basic Information

Product Name	(2R,5S)-Thiolane-2,5-Dicarboxamide
CAS No.	1932206-73-9
Molecular Formula	C6H10N2O2S
Molecular Weight	174.22 g/mol
Synonyms	(2R,5S)-Tetrahydrothiophene-2,5-dicarboxamide; (2R,5S)-2,5-Dicarbamoylthiolane; (2R,5S)-Thiolane-2,5-dicarboxylic acid diamide; (2R,5S)-2,5-Bis(aminocarbonyl)thiolane; (2R,5S)-2,5-Diaminocarbonyltetrahydrothiophene; (2R,5S)-2,5-Dicarboxamidothiolane; (2R,5S)-2,5-Dicarbamoyltetrahydrothiophene
EINECS	Contact for details

Quality Control

Our (2R,5S)-Thiolane-2,5-Dicarboxamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with research-grade and custom synthesis specifications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles is provided with every shipment to guarantee reproducible results for your critical R&D workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption, which may affect stability and handling properties. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.