Description

Fmoc-3,4-Dehydro-L-Val-Oh CAS NO 1932087-73-4 is a specialized, non-proteinogenic amino acid derivative featuring a dehydrovaline backbone protected by a fluorenylmethyloxycarbonyl (Fmoc) group. This compound is critically important for the synthesis of complex peptides and peptidomimetics, where it introduces conformational constraints and unique structural motifs to modulate biological activity and stability. It is an essential building block for researchers and manufacturers in pharmaceutical development, particularly in the discovery of novel therapeutics, and for the production of custom peptides in biotechnology.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key Fmoc-protected amino acid for the automated, stepwise construction of peptides, enabling the incorporation of a rigid dehydrovaline residue.
• Peptidomimetic Drug Discovery: Used to create constrained peptide analogs with enhanced metabolic stability, receptor selectivity, and bioavailability for potential therapeutic agents.
• Bioconjugation and Probe Development: Serves as a modified amino acid component in the synthesis of labeled peptides for biochemical assays, imaging, and diagnostic applications.
• Academic and Industrial Research: A vital reagent for studying structure-activity relationships (SAR) in peptide science and for developing new synthetic methodologies.
• Production of Custom Bioactive Peptides: Employed by CROs and CDMOs to manufacture peptides with specific, engineered properties for client projects.

Basic Information

Product Name	Fmoc-3,4-Dehydro-L-Val-Oh
CAS No.	1932087-73-4
Molecular Formula	C₂₁H₂₁NO₄
Molecular Weight	351.40 g/mol
Synonyms	Fmoc-δVal-OH; Fmoc-(3,4-dehydro)-L-valine; N-(9-Fluorenylmethoxycarbonyl)-3,4-dehydro-L-valine; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-3-methylbut-3-enoic acid; Fmoc-DhV-OH; N-α-Fmoc-dehydrovaline; Fmoc-3,4-didehydro-L-valine
EINECS	Contact for details

Quality Control

Every batch of Fmoc-3,4-Dehydro-L-Val-Oh is produced and tested under strict quality management systems to ensure it meets the high-purity standards required for sensitive peptide synthesis. Our products undergo rigorous quality testing, including advanced chromatographic analysis, to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. For long-term storage, consider desiccant and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.