Description

(R)-2-(Boc-Amino)-2-Methylhex-5-Enoic Acid CAS NO 1932061-85-2 is a high-purity, non-natural amino acid derivative featuring a chiral center and a terminal alkene functional group. This compound is a critical chiral building block for the synthesis of complex peptides and peptidomimetics, enabling the introduction of structural diversity and specific stereochemistry. It is primarily utilized by pharmaceutical R&D and process chemistry teams for the development of active pharmaceutical ingredients (APIs), proteolysis-targeting chimeras (PROTACs), and other bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and commercial synthesis of novel therapeutic peptides and small molecule drugs.
• PROTAC Linker Component: Used in the construction of the linker region of Proteolysis-Targeting Chimeras due to its defined stereochemistry and functional handles.
• Peptide Chemistry: Serves as a protected, side-chain functionalized amino acid for solid-phase and solution-phase peptide synthesis (SPPS).
• Chemical Biology Probes: Incorporated into peptide-based probes for studying protein-protein interactions and enzyme function.
• Asymmetric Synthesis: Employed as a starting material or intermediate in asymmetric catalytic reactions to construct complex chiral architectures.
• Material Science: Potential monomer for creating specialized polymers with peptide-like backbones for biomedical applications.

Basic Information

Product Name	(R)-2-(Boc-Amino)-2-Methylhex-5-Enoic Acid
CAS No.	1932061-85-2
Molecular Formula	C₁₃H₂₃NO₄
Molecular Weight	257.33 g/mol
Synonyms	(R)-2-((tert-Butoxycarbonyl)amino)-2-methylhex-5-enoic acid; Boc-D-2-Methyl-2-amino-5-hexenoic Acid; (R)-2-(Boc-amino)-2-methyl-5-hexenoic acid; (2R)-2-[(tert-Butoxycarbonyl)amino]-2-methyl-5-hexenoic Acid; (R)-Boc-Amino-2-methyl-5-hexenoic Acid; (R)-N-Boc-2-amino-2-methyl-5-hexenoic acid; Boc-(R)-Amino(2-methyl-5-hexenoic) Acid
EINECS	Contact for details

Quality Control

Our (R)-2-(Boc-Amino)-2-Methylhex-5-Enoic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric purity and NMR for structural confirmation, to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) specifying purity, chiral purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions. Keep container tightly sealed in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.