Description

n-Boc-1-(trans-4-Ethynylcyclohexyl)Methanamine is a high-purity, protected amine building block featuring a rigid cyclohexyl scaffold and a terminal alkyne functional group. This compound is specifically engineered for advanced pharmaceutical research and development, serving as a critical intermediate in the synthesis of complex bioactive molecules. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical, biotechnology, and agrochemical industries for constructing novel drug candidates and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of small molecule drug candidates, particularly in oncology and CNS therapeutic areas.
• Peptidomimetic Synthesis: Used to introduce constrained, alkyne-functionalized cyclohexyl motifs into peptide backbones to enhance stability and bioavailability.
• Click Chemistry Substrate: The terminal alkyne group enables efficient copper-catalyzed azide-alkyne cycloaddition (CuAAC) for bioconjugation and polymer functionalization.
• Ligand and Catalyst Development: Serves as a precursor for creating novel chiral ligands and organometallic catalysts.
• Agrochemical Research: Intermediate in the development of new herbicides and plant growth regulators with tailored properties.
• Material Science: Building block for advanced polymers and dendrimers with specific architectural features.

Basic Information

Product Name	n-Boc-1-(trans-4-Ethynylcyclohexyl)Methanamine
CAS No.	1932050-98-0
Molecular Formula	C14H23NO2
Molecular Weight	237.34 g/mol
Synonyms	1-[(1,1-Dimethylethoxy)carbonyl]-4-(ethynyl)cyclohexanemethanamine (trans-); tert-Butyl N-[(trans-4-ethynylcyclohexyl)methyl]carbamate; trans-4-(Aminomethyl)cyclohexaneacetonitrile, N-Boc protected; Boc-trans-4-ethynylcyclohexylmethylamine; (trans-4-Ethynylcyclohexyl)methanamine, N-Boc derivative; BOC-Trans-4-Ethynyl-CHMA; 1932050-98-0; tert-Butyl ((trans-4-ethynylcyclohexyl)methyl)carbamate
EINECS	Contact for details

Quality Control

Our n-Boc-1-(trans-4-Ethynylcyclohexyl)Methanamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.