Description

Ethyl (1R,3R,4R)-4-Fluoro-3-Hydroxycyclohexane-1-Carboxylate is a high-purity, stereochemically defined fluorinated cyclohexane derivative that serves as a critical chiral building block in advanced organic synthesis. Its value lies in the precise spatial arrangement of its functional groups, enabling the construction of complex molecules with defined three-dimensional architectures. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for developing active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of fluorinated drug candidates, especially in central nervous system (CNS) and metabolic disease research.
• Agrochemical Development: Used in creating novel, stereoselective pesticides and herbicides where the fluorine atom enhances bioavailability and metabolic stability.
• Asymmetric Catalysis: Serves as a sophisticated ligand precursor or a test substrate for developing new catalytic methodologies.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to explore the impact of fluorination and stereochemistry on biological activity.
• Fine Chemical Synthesis: A versatile intermediate for producing other fluorinated fine chemicals and specialty materials.

Basic Information

Item	Detail
Product Name	Ethyl (1R,3R,4R)-4-Fluoro-3-Hydroxycyclohexane-1-Carboxylate
CAS No.	1932015-48-9
Molecular Formula	C9H15FO3
Molecular Weight	190.21 g/mol
Synonyms	(1R,3R,4R)-Ethyl 4-Fluoro-3-hydroxycyclohexanecarboxylate; Ethyl (1R,3R,4R)-4-Fluoro-3-hydroxycyclohexane-1-carboxylate; (1R,3R,4R)-4-Fluoro-3-hydroxycyclohexanecarboxylic Acid Ethyl Ester; trans-4-Fluoro-3-hydroxycyclohexanecarboxylic Acid Ethyl Ester (specifying (1R,3R,4R)); Fluorocyclohexanol Carboxylate Ester; CAS 1932015-48-9
EINECS	Contact for details

Quality Control

Our Ethyl (1R,3R,4R)-4-Fluoro-3-Hydroxycyclohexane-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC to ensure enantiomeric and diastereomeric purity, NMR for structural confirmation, and GC/HPLC for chemical purity and impurity profiling. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de (diastereomeric excess)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.