Description

[Glu17,21,24]-Osteocalcin (1-49) (Human) is a synthetic, post-translationally modified peptide fragment of human osteocalcin, a key non-collagenous protein found in bone. This specific variant, featuring carboxylated glutamic acid residues at positions 17, 21, and 24, is crucial for research into bone metabolism, calcium homeostasis, and vitamin K-dependent protein function. It serves as an essential reference standard and active ingredient for scientists and developers in pharmaceutical research, clinical diagnostics, and metabolic bone disease studies.

Application

• Biomedical Research Standard: Used as a high-purity reference standard in quantitative assays (e.g., ELISA) to measure undercarboxylated osteocalcin (ucOC) levels, a biomarker for bone turnover and vitamin K status.
• Diagnostic Kit Development: Critical raw material for the development and calibration of immunoassay kits targeting human osteocalcin isoforms for clinical diagnostics.
• Mechanistic Studies: Facilitates in vitro and in vivo research on osteocalcin's role in glucose metabolism, insulin sensitivity, and endocrine function of bone.
• Pharmaceutical R&D: Employed in drug discovery programs targeting bone-related disorders such as osteoporosis, osteoarthritis, and chronic kidney disease-mineral and bone disorder (CKD-MBD).
• Quality Control: Serves as a system suitability standard in analytical laboratories for method validation and ensuring assay precision and accuracy.

Basic Information

Product Name	[Glu17,21,24]-Osteocalcin (1-49) (Human)
CAS No.	1927927-11-4
Molecular Formula	C254H386N70O79
Molecular Weight	~5960.3 g/mol
Synonyms	Undercarboxylated Osteocalcin (1-49), Human; ucOC (1-49); Gla-type Osteocalcin; Bone Gla Protein Fragment (1-49); BGP (1-49); Osteocalcin, human (1-49), [Gla17,21,24]-; N-terminal Osteocalcin Fragment; Carboxylated Osteocalcin Peptide
EINECS	Contact for details

Quality Control

Our [Glu17,21,24]-Osteocalcin (1-49) (Human) is manufactured under strict quality systems. Each batch is characterized and tested to ensure high purity, correct sequence, and precise modification. Identity is confirmed by mass spectrometry (MS) and analytical HPLC. Certificates of Analysis (COA) detailing purity (by HPLC), peptide content, amino acid analysis, and endotoxin levels are provided to support your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (MS)	Consistent with theoretical molecular weight
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by amino acid analysis)
Amino Acid Composition	Conforms to theoretical sequence
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Endotoxin	< 10 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.