Description

(H-Glu(Cys-[15N]Gly-Oh)-Oh)2 is a stable, isotopically labeled peptide dimer, specifically incorporating nitrogen-15 (15N) in the glycine residue. This compound is of significant value for research requiring precise metabolic tracing and quantification in complex biological systems. It is primarily needed by pharmaceutical R&D teams, academic research institutions, and contract research organizations (CROs) focused on proteomics, biomarker discovery, and pharmacokinetic studies.

Application

• Internal Standard for Mass Spectrometry (MS): Used as a quantitative reference standard in LC-MS/MS and GC-MS analyses for accurate peptide and protein quantification.
• Metabolic Pathway Tracing: Employed in proteomics and metabolomics research to track the incorporation and turnover of labeled amino acids.
• Pharmaceutical Development: Serves as a critical tool in the development and validation of bioanalytical methods for novel therapeutic peptides.
• Biomarker Research: Facilitates the discovery and validation of disease-specific protein biomarkers through stable isotope dilution techniques.
• Nutritional Studies: Applied in research investigating protein metabolism, amino acid absorption, and utilization.

Basic Information

Product Name	(H-Glu(Cys-[15N]Gly-Oh)-Oh)2
CAS No.	1926163-36-1
Molecular Formula	C20H32N6O12S2
Molecular Weight	612.63 g/mol
Synonyms	Bis(L-γ-glutamyl-L-cysteinyl-[15N]glycine); L-γ-Glutamyl-L-cysteinyl-[15N]glycine dimer; [15N]Gly-labeled glutathione precursor dimer; ECG ([15N]) dimer; (γ-Glu-Cys-[15N]Gly)2; Isotope-labeled γ-glutamylcysteine glycine dimer; S-(Carboxymethyl)-L-cysteine, N-[N-L-γ-glutamyl-L-cysteinyl-[15N]glycyl]-, cyclic disulfide
EINECS	Contact for details

Quality Control

Our isotopically labeled compounds are produced under strict quality control protocols to ensure the highest chemical and isotopic purity. Each batch is characterized by advanced analytical techniques including NMR, HPLC, and mass spectrometry to confirm structure, isotopic enrichment (>98 atom % 15N), and purity. Certificates of Analysis (COA) detailing all specifications are provided and we support compliance with relevant GMP/GLP guidelines for research use.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation and hydrolysis. The product is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to theoretical mass
Purity (HPLC)	≥ 95.0%
Isotopic Enrichment (15N NMR/MS)	≥ 98 atom % 15N
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.