Description

(Des-His)-Acth (1-24) (Human, Bovine, Rat) is a synthetic peptide fragment of adrenocorticotropic hormone (ACTH) with the histidine residue at position 6 removed. This modification is critical for research into the structure-activity relationships of ACTH and its receptor interactions. It serves as a valuable biochemical tool for endocrinology and neuroscience research, particularly in studies of the hypothalamic-pituitary-adrenal (HPA) axis. This high-purity peptide is essential for pharmaceutical R&D, academic laboratories, and diagnostic kit manufacturers requiring precise and reliable bioactive compounds.

Application

• Biochemical Research: Used as a reference standard and active agent in studies of ACTH receptor binding, signal transduction, and steroidogenesis.
• Pharmaceutical Development: Serves as a key intermediate or reference compound in the development of novel therapeutics targeting adrenal function and stress-related disorders.
• Diagnostic Assays: Employed in the calibration and development of immunoassays (e.g., ELISA, RIA) for measuring ACTH levels in clinical and research settings.
• Neuroscience Studies: Applied in research investigating the role of the HPA axis in behavior, stress response, and neurological conditions.
• Endocrinology: Utilized to study adrenal cortex stimulation and the synthesis of corticosteroids in vitro and in vivo models.
• Peptide Chemistry: Acts as a model compound for studying peptide stability, modification, and analytical method development.

Basic Information

Item	Details
Product Name	(Des-His)-Acth (1-24) (Human, Bovine, Rat)
CAS No.	1926163-11-2
Molecular Formula	C136H210N40O31S
Molecular Weight	2933.4 g/mol
Synonyms	Des-His6-ACTH (1-24); Adrenocorticotropic Hormone (1-24), Des-His6-; ACTH (1-24) amide, Des-His6-; Cortrosyn fragment (1-24), Des-His6-; Tetracosactide, Des-His6-; Synacthen fragment, Des-His6-; [Des-His6]-ACTH (1-24); Cosyntropin fragment, Des-His6-
EINECS	Contact for details

Quality Control

Our (Des-His)-Acth (1-24) (Human, Bovine, Rat) is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation and mass spectrometry for structural verification. We provide full traceability and Certificates of Analysis (COA) detailing all critical parameters to ensure compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere. Allow the vial to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with theoretical molecular weight
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0% (by weight)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Single Impurity (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.