Description

Ataluren-D4 is a deuterated analog of Ataluren, a pharmaceutical compound designed for research and development purposes. This stable isotope-labeled compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring high accuracy and reliability in analytical studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions conducting pharmacokinetic, metabolic, and bioanalytical research.

Application

• Internal Standard for LC-MS/MS: Serves as a critical internal standard for the precise quantification of Ataluren in biological matrices (e.g., plasma, serum, urine) using liquid chromatography-tandem mass spectrometry (LC-MS/MS).
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Enables accurate tracking of the parent drug's absorption, distribution, metabolism, and excretion (ADME) profiles in preclinical and clinical research.
• Bioanalytical Method Development and Validation: Used to develop, validate, and ensure the robustness and regulatory compliance of bioanalytical assays.
• Metabolite Identification and Profiling: Aids in distinguishing drug-derived metabolites from endogenous compounds in complex biological samples.
• Pharmaceutical Quality Control: Supports analytical methods for assessing drug substance and product purity and stability in manufacturing environments.

Basic Information

Product Name	Ataluren-D4
CAS No.	1922064-61-6
Molecular Formula	C15H8D4N2O5
Molecular Weight	288.28 g/mol (approximate)
Synonyms	3-[5-(2-Fluorophenyl)-1,2,4-oxadiazol-3-yl]-D4-benzoic acid; PTC124-D4; Translarna-D4; Ataluren deuterated; Ataluren-d4; (3-(5-(2-Fluorophenyl)-1,2,4-oxadiazol-3-yl)benzoic-2,3,5,6-d4 acid); Deuteration at phenyl ring positions 2,3,5,6
EINECS	Contact for details

Quality Control

Our Ataluren-D4 is manufactured under strict quality systems to ensure high chemical and isotopic purity suitable for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic enrichment, chemical purity (by HPLC), and residual solvent content. We adhere to relevant industry standards for research chemicals, and custom purity grades or specific analytical data packages are available upon request to meet your precise study protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (D-content)	≥98.0 atom % D
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.