Description

Oxazole, 2-[2-(Diphenylphosphino)Phenyl]-4,5-Dihydro-4,5-Diphenyl-, (4S,5S)- is a sophisticated chiral organophosphorus-oxazole hybrid ligand, a key building block in advanced asymmetric catalysis. Its value lies in its ability to induce high enantioselectivity in transition metal-catalyzed reactions, which is critical for producing single-isomer pharmaceutical intermediates and fine chemicals. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop efficient and selective synthetic routes.

Application

• As a chiral ligand in asymmetric hydrogenation reactions for the synthesis of enantiomerically pure amino acid derivatives and pharmaceutical actives.
• Catalyst component for asymmetric C-C and C-X (X = N, O) bond-forming reactions, such as cross-couplings and allylic substitutions.
• Precursor for the development of novel catalyst systems in academic and industrial research focused on green chemistry and sustainable processes.
• Critical reagent in the synthesis of complex natural products and high-value chiral intermediates where stereochemical control is paramount.
• Used in the preparation of specialized materials where chiral induction at a metal center is required for specific electronic or optical properties.

Basic Information

Product Name	Oxazole, 2-[2-(Diphenylphosphino)Phenyl]-4,5-Dihydro-4,5-Diphenyl-, (4S,5S)-
CAS No.	1918125-85-5
Molecular Formula	C39H30NOP
Molecular Weight	559.64 g/mol
Synonyms	(4S,5S)-2-[2-(Diphenylphosphino)phenyl]-4,5-diphenyl-4,5-dihydrooxazole; (4S,5S)-PHOX Ligand; (S,S)-2-[2-(Diphenylphosphino)phenyl]-4,5-diphenyl-2-oxazoline; Chiral PHOX Ligand; P,N-Ligand; (S,S)-iPr-PHOX analog; Asymmetric hydrogenation ligand; Chiral oxazoline-phosphine ligand
EINECS	Contact for details

Quality Control

Every batch of our chiral ligands is produced and tested under strict quality protocols to ensure high chemical and enantiomeric purity, which is critical for catalytic performance. We provide comprehensive Certificates of Analysis (COA) detailing identity (NMR, IR), purity (HPLC), chiral purity (Chiral HPLC), and other relevant physicochemical data. Our quality system is designed to support cGMP and ISO standards for advanced synthetic intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C or as specified on the label or COA. This compound is easily oxidized and light-sensitive; prolonged exposure to air, moisture, or light may degrade its catalytic efficacy.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.