Description

Remdesivir Metabolite CAS NO 1911578-76-1 is a key intermediate and reference standard in the synthesis and analytical profiling of the antiviral drug Remdesivir. This compound is critical for pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics, and the production of high-purity active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and analytical laboratories engaged in antiviral drug development and quality control.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantification and identification of Remdesivir metabolites in biological matrices and drug substance analysis.
• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a crucial synthetic intermediate in the multi-step manufacturing process of Remdesivir and its prodrug forms.
• Metabolite Profiling & Pharmacokinetic Studies: Essential for in-vitro and in-vivo studies to understand the metabolic pathways, distribution, and elimination of Remdesivir.
• Analytical Method Development & Validation: Employed in HPLC, LC-MS, and other chromatographic methods to calibrate equipment and validate analytical procedures for regulatory submissions.
• Impurity Identification and Control: Acts as a known impurity or degradation product standard to establish specification limits and ensure final drug product purity and safety.
• Biomedical Research: Used in academic and institutional research to investigate the mechanism of action and efficacy of nucleotide analog antivirals against RNA viruses.

Basic Information

Product Name	Remdesivir Metabolite
CAS No.	1911578-76-1
Molecular Formula	C27H35N6O8P
Molecular Weight	602.58 g/mol
Synonyms	GS-441524 Triphosphate; GS-441524 TP; GS-5734 Metabolite; (2R,3R,4R,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-((hydroxy(phosphonooxy)phosphoryl)oxy)methyl)tetrahydrofuran-3,4-diol; Remdesivir Nucleoside Triphosphate; GS-441524 Triphosphoric Acid; AL-10 (Remdesivir) Metabolite; Remdesivir Active Triphosphate Metabolite
EINECS	Contact for details

Quality Control

Our Remdesivir Metabolite is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and impurities. We provide Certificates of Analysis (COA) with each shipment, detailing all specifications and test results to support your regulatory and research needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, inert environment. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.