Description

Dota Zoledronate CAS NO 1908409-18-6 is a high-purity bisphosphonate compound, a key intermediate in advanced pharmaceutical research and development. This material is critical for the synthesis of novel therapeutic agents targeting bone metabolism disorders. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and manufacturers of active pharmaceutical ingredients (APIs) focused on metabolic and oncological treatments.

Application

• Pharmaceutical Intermediate: Primary use in the synthesis of next-generation bisphosphonate drugs and related therapeutic compounds.
• Research & Development: Serves as a critical building block in medicinal chemistry for developing new treatments for osteoporosis and Paget's disease.
• Active Pharmaceutical Ingredient (API) Synthesis: Used in the controlled production of zoledronic acid derivatives and other bone-targeting agents.
• Biochemical Research: Employed in studies investigating the mechanism of action of bisphosphonates on osteoclast activity and bone resorption.
• Reference Standard: Can be utilized as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	Dota Zoledronate
CAS No.	1908409-18-6
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	DOTA-conjugated Zoledronate; 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid Zoledronate conjugate; Zoledronic acid DOTA derivative; DOTA-ZOL; DOTA-Zoledronic Acid; Diagnostic/Therapeutic Bisphosphonate Conjugate
EINECS	Contact for details

Quality Control

Our Dota Zoledronate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical intermediate applications. Certificates of Analysis (COA) documenting all critical quality attributes are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.