Description

2-Propanesulfinamide, n-[(1R)-1-[2-(Diphenylphosphino)Phenyl]-2,2-Dimethylpropyl]-2-Methyl-, [S(R)]- is a sophisticated chiral sulfinamide-phosphine hybrid ligand, a key building block in modern asymmetric synthesis. Its value lies in its ability to induce high enantioselectivity in transition metal-catalyzed reactions, which is critical for producing single-isomer active pharmaceutical ingredients (APIs) and fine chemicals. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors who require precise stereochemical control.

Application

• Asymmetric Catalysis: Serves as a privileged chiral ligand for transition metals like rhodium, iridium, and palladium in enantioselective hydrogenation, C-C bond formation, and other key transformations.
• Pharmaceutical Intermediate Synthesis: Critical for the development and scalable production of chiral drug candidates, enabling the creation of single-enantiomer APIs with high purity.
• Agrochemical Research: Used in the synthesis of enantiomerically pure herbicides, fungicides, and plant growth regulators where biological activity is often stereospecific.
• Methodology Development: A valuable tool for academic and industrial researchers developing new catalytic asymmetric synthetic routes.
• Fine Chemical Production: Employed in the manufacture of high-value, complex chiral molecules for flavors, fragrances, and electronic chemicals.

Basic Information

Product Name	2-Propanesulfinamide, n-[(1R)-1-[2-(Diphenylphosphino)Phenyl]-2,2-Dimethylpropyl]-2-Methyl-, [S(R)]-
CAS No.	1906918-20-4
Molecular Formula	C29H36NOPS
Molecular Weight	477.63 g/mol
Synonyms	(SR)-N-[(1R)-1-[2-(Diphenylphosphino)phenyl]-2,2-dimethylpropyl]-2-methylpropane-2-sulfinamide; (R)-DTBM-SEGPHOS Sulfinamide Derivative; Chiral Sulfinyl Phosphine Ligand; tert-Butanesulfinamide Phosphine Hybrid Ligand; Asymmetric Sulfinamide-Phosphine Ligand; N-[(1R)-1-[2-(Diphenylphosphino)phenyl]-2,2-dimethylpropyl]-2-methylpropane-2-sulfinamide, (SR)-; P-Chiral Sulfinamide Ligand
EINECS	Contact for details

Quality Control

Every batch of this high-value chiral ligand is produced and analyzed under strict quality control protocols to ensure consistency and performance in sensitive catalytic applications. Identity and purity are confirmed via advanced analytical techniques including HPLC, NMR, and chiral analysis. A comprehensive Certificate of Analysis (COA) detailing assay, enantiomeric excess, and impurity profiles is provided with each shipment to support your regulatory and R&D documentation.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to maintain stability and prevent oxidation. The container should be kept in a cool, dry, and well-ventilated area, separate from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.