Description

Oxazole, 2-[2-(Diphenylphosphino)Phenyl]-4,5-Dihydro-4-(1-Methylethyl)-5,5-Diphenyl-, (4R)- is a sophisticated chiral organophosphorus-oxazole hybrid ligand, identified by CAS No. 1904575-43-4. This compound is engineered to provide exceptional stereoselectivity and catalytic activity in asymmetric synthesis, a critical requirement for producing high-value, optically pure intermediates. It is primarily sought after by research and development teams in the pharmaceutical and fine chemical sectors for the development of novel active pharmaceutical ingredients (APIs) and advanced materials.

Application

• Asymmetric Catalysis: As a privileged chiral ligand for transition metal-catalyzed reactions, including hydrogenation, cross-coupling, and hydroformylation.
• Pharmaceutical Intermediate Synthesis: For the stereoselective construction of complex molecular architectures in API development.
• Academic & Industrial Research: A key reagent in methodological studies for developing new catalytic systems and synthetic pathways.
• Fine Chemical Production: Enabling the manufacture of enantiomerically pure flavors, fragrances, and agrochemical intermediates.
• Material Science: Potential use in the synthesis of chiral polymers or metal-organic frameworks (MOFs) with specific optical properties.

Basic Information

Product Name	Oxazole, 2-[2-(Diphenylphosphino)Phenyl]-4,5-Dihydro-4-(1-Methylethyl)-5,5-Diphenyl-, (4R)-
CAS No.	1904575-43-4
Molecular Formula	C36H32NOP
Molecular Weight	525.62 g/mol
Synonyms	(4R)-2-[2-(Diphenylphosphino)phenyl]-4-isopropyl-5,5-diphenyl-4,5-dihydrooxazole; (R)-2-[2-(Diphenylphosphino)phenyl]-4-isopropyl-5,5-diphenyl-4,5-dihydrooxazole; Chiral PHOX Ligand Derivative; P,N-Ligand; Josiphos-type Oxazole Ligand; Asymmetric Dihydrooxazole Phosphine Ligand
EINECS	Contact for details

Quality Control

Every batch of our chiral ligands is produced and analyzed under stringent quality protocols to ensure high enantiomeric excess (ee) and chemical purity, critical for reproducible catalytic performance. Our quality assurance includes advanced analytical techniques such as chiral HPLC, 31P NMR, and 1H NMR. A comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral purity, and residual solvent content is provided with each shipment to support your quality and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. Due to its sensitivity, the container should be kept sealed to minimize exposure to air and moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.