Description

Boc-Aminooxy-Peg4-Propargyl CAS NO 1895922-77-6 is a heterobifunctional polyethylene glycol (PEG) linker featuring a Boc-protected aminooxy group and a terminal propargyl group. This compound is essential for creating stable, site-specific bioconjugates and functionalized materials via orthogonal click chemistry and oxime ligation strategies. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors for developing antibody-drug conjugates (ADCs), peptide/protein modifications, and hydrogel networks.

Application

• Bioconjugation and ADC Development: Site-specific conjugation of drugs, toxins, or fluorophores to antibodies, proteins, or peptides via oxime ligation and copper-catalyzed azide-alkyne cycloaddition (CuAAC).
• PEGylation and Linker Chemistry: Serving as a versatile, hydrophilic spacer to improve solubility, reduce immunogenicity, and extend the circulation half-life of therapeutic biomolecules.
• Surface Functionalization and Material Science: Modifying nanoparticles, biosensors, or solid supports to create bioactive surfaces for diagnostic assays or tissue engineering scaffolds.
• Chemical Biology and Probe Synthesis: Constructing activity-based probes or affinity tags for studying protein function, localization, and interactions in complex biological systems.
• Cross-linking and Hydrogel Formation: Acting as a cross-linker in the synthesis of smart hydrogels and biomaterials with tailored mechanical and release properties.

Basic Information

Product Name	Boc-Aminooxy-Peg4-Propargyl
CAS No.	1895922-77-6
Molecular Formula	C22H40N2O9
Molecular Weight	476.56 g/mol
Synonyms	1-Boc-aminooxy-3,6,9,12-tetraoxapentadec-14-yn-15-ol; 15-Amino-4,7,10,13-tetraoxa-1-azaheptadec-16-ynoic acid tert-butyl ester; Boc-NH-O-PEG4-propargyl; tert-Butyl N-(17-hydroxy-3,6,9,12-tetraoxa-16-heptadecyn-1-yloxy)carbamate; Aminooxy-PEG4-Propargyl, Boc-protected; Propargyl-PEG4-aminooxy, Boc; Boc-Aminooxy-PEG4-Alkyne; t-Butyloxycarbonyl-aminooxy-tetraethylene glycol-propargyl ether
EINECS	Contact for details

Quality Control

Our Boc-Aminooxy-Peg4-Propargyl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent performance. Certificates of Analysis (COA) with detailed specifications are provided to guarantee compliance with research and cGMP-grade material standards for critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) in a dry, cool environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or oil
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.