Description

(6-Methyl-5-(Trifluoromethyl)Pyridin-3-Yl)Boronic Acid is a high-value organoboron building block essential for modern synthetic chemistry. Its core value lies in enabling the precise construction of complex molecules through efficient cross-coupling reactions like the Suzuki-Miyaura reaction. This compound is critically needed by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients. Its unique trifluoromethyl-substituted pyridine scaffold is particularly valuable for creating compounds with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), especially for candidates targeting central nervous system (CNS) disorders, oncology, and inflammation.
• Agrochemical Research: Used to construct novel pyridine-based herbicides, fungicides, and insecticides, leveraging the bioactivity-enhancing properties of the trifluoromethyl group.
• Material Science: Serves as a precursor for creating advanced organic electronic materials, such as ligands for OLEDs or charge-transport materials.
• Suzuki-Miyaura Cross-Coupling: Primarily employed as a boronic acid coupling partner with aryl/heteroaryl halides to form biaryl and heterobiaryl linkages under palladium catalysis.
• Medicinal Chemistry & Drug Discovery: Facilitates rapid analog synthesis and structure-activity relationship (SAR) studies in lead optimization campaigns.
• Chemical Biology Probe Development: Used to create tagged molecules for studying biological pathways and protein interactions.

Basic Information

Product Name	(6-Methyl-5-(Trifluoromethyl)Pyridin-3-Yl)Boronic Acid
CAS No.	1889221-15-1
Molecular Formula	C7H7BF3NO2
Molecular Weight	204.95 g/mol
Synonyms	[5-(Trifluoromethyl)-6-methyl-3-pyridinyl]boronic acid; 3-Borono-5-(trifluoromethyl)-6-picoline; (6-Methyl-5-(trifluoromethyl)pyridin-3-yl)boronic acid; 5-(Trifluoromethyl)-6-methylpyridine-3-boronic acid; Boronic acid, B-[5-(trifluoromethyl)-6-methyl-3-pyridinyl]-; 3-Pyridineboronic acid, 5-(trifluoromethyl)-6-methyl-
EINECS	Contact for details

Quality Control

Our (6-Methyl-5-(Trifluoromethyl)Pyridin-3-Yl)Boronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure compliance with exacting R&D and process chemistry standards. Comprehensive Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.