Description

Phenol, 3-Fluoro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- is a high-value, multi-functional boronic ester derivative, serving as a critical building block in modern synthetic chemistry. Its core value lies in enabling efficient, precise carbon-carbon bond formation via the Suzuki-Miyaura cross-coupling reaction, a cornerstone of pharmaceutical and advanced materials research. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and organic electronics industries who require reliable, high-purity intermediates for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing fluorinated aromatic systems.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require specific fluorinated phenol motifs.
• Material Science: Precursor for creating functionalized polymers, liquid crystals, and organic light-emitting diodes (OLEDs) through cross-coupling reactions.
• Chemical Research: Versatile reagent in academic and industrial laboratories for methodology development and the synthesis of complex organic molecules.
• Ligand & Catalyst Development: Serves as a starting material for synthesizing novel bidentate ligands and organometallic catalysts.
• Fluorine Chemistry: A valuable synthon for introducing both fluorine and boronate functional groups into target molecules in a single step.

Basic Information

Product Name	Phenol, 3-Fluoro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-
CAS No.	1887126-77-3
Molecular Formula	C12H16BFO3
Molecular Weight	238.07 g/mol
Synonyms	3-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol; (3-Fluoro-5-hydroxyphenyl)boronic acid pinacol ester; 5-Hydroxy-3-fluorophenylboronic acid pinacol ester; 2-(3-Fluoro-5-hydroxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 3-Fluoro-5-(pinacolatoboryl)phenol; 3-Fluoro-5-hydroxybenzeneboronic acid pinacol ester; 3-Fluoro-5-pinacolatoborylphenol
EINECS	Contact for details

Quality Control

Our Phenol, 3-Fluoro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and structural integrity suitable for demanding synthetic applications. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) in a desiccator for long-term preservation. Recommended storage temperature: 2-8°C for optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.