Description

2,5-Difluoro-6-Methylphenylboronic Acid is a high-purity organoboron compound serving as a critical building block in modern synthetic chemistry. Its value lies in enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex molecular architectures. This boronic acid is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality intermediates for developing active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for fluorinated drug candidates targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used to construct novel, fluorinated herbicides, fungicides, and insecticides, where the difluoro-methylphenyl moiety can enhance biological activity and environmental stability.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of organic electronic materials, such as polymers for OLEDs and OFETs.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for transition metal catalysis and as a scaffold for boron-based sensor molecules.
• Chemical Biology & Proteomics: Utilized in the design and synthesis of chemical probes and bioconjugation reagents for studying biological systems.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs serving the global life sciences industry.

Basic Information

Product Name	2,5-Difluoro-6-Methylphenylboronic Acid
CAS No.	1884277-68-2
Molecular Formula	C7H7BF2O2
Molecular Weight	171.94 g/mol
Synonyms	(2,5-Difluoro-6-methylphenyl)boronic acid; 2,5-Difluoro-6-methylbenzeneboronic acid; 6-Methyl-2,5-difluorophenylboronic acid; Boronic acid, B-(2,5-difluoro-6-methylphenyl)-; 1884277-68-2; 2,5-Difluoro-6-methylphenyl-B(OH)2
EINECS	Contact for details

Quality Control

Every batch of 2,5-Difluoro-6-Methylphenylboronic Acid is manufactured under strict quality management systems. We employ advanced analytical techniques, including HPLC, NMR, and LC-MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing batch-specific results are provided and can be tailored to meet specific customer or regulatory requirements, supporting applications in GMP environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Assay (HPLC)	≥97.0%
Purity (HPLC, Area%)	≥98.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.