Description

(2-Fluoro-3-(Methylsulfonyl)Phenyl)Boronic Acid Pinacol Ester is a high-value organoboron building block, specifically a protected boronic ester, designed for advanced cross-coupling reactions. Its core value lies in enabling the precise and efficient synthesis of complex molecules, particularly in pharmaceutical research where the introduction of fluorine and methylsulfonyl groups is critical for modulating biological activity and physicochemical properties. This compound is essential for medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries who require reliable, high-purity intermediates for Suzuki-Miyaura and other palladium-catalyzed couplings.

Application

• Pharmaceutical Intermediate: A key building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, especially those targeting central nervous system (CNS) disorders, oncology, and inflammatory diseases.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging the fluorine atom for enhanced metabolic stability and bioavailability.
• Material Science Research: Serves as a precursor for creating functionalized polymers, liquid crystals, and organic electronic materials through cross-coupling polymerization.
• Chemical Biology & Probe Development: Employed in the synthesis of molecular probes and labeled compounds for studying biological pathways and target engagement.
• Process Chemistry & Scale-up: Provides a stable, handling-friendly alternative to the corresponding boronic acid for large-scale GMP manufacturing of complex molecules.
• Library Synthesis for Drug Discovery: Facilitates the rapid generation of diverse compound libraries via parallel synthesis for high-throughput screening (HTS) campaigns.

Basic Information

Product Name	(2-Fluoro-3-(Methylsulfonyl)Phenyl)Boronic Acid Pinacol Ester
CAS No.	1876473-43-6
Molecular Formula	C₁₄H₂₀BFO₄S
Molecular Weight	314.18 g/mol
Synonyms	2-Fluoro-3-(methylsulfonyl)benzeneboronic acid pinacol ester; (2-Fluoro-3-methanesulfonylphenyl)boronic acid pinacol ester; [2-Fluoro-3-(methylsulfonyl)phenyl]boronic acid pinacol ester; Pinacol [2-fluoro-3-(methylsulfonyl)phenyl]boronate; Boronic acid, B-[2-fluoro-3-(methylsulfonyl)phenyl]-, 1,1-dimethylethyl ester; 3-(Methylsulfonyl)-2-fluorophenylboronic acid pinacol ester; CAS 1876473-43-6
EINECS	Contact for details

Quality Control

Our (2-Fluoro-3-(Methylsulfonyl)Phenyl)Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high chemical purity and structural integrity suitable for sensitive cross-coupling applications. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are provided to guarantee traceability and batch-to-batch consistency, meeting the stringent requirements of research and development laboratories.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.