Description

(Asp37)-Amyloid B-Protein (1-42) Trifluoroacetate is a specifically modified peptide fragment of the amyloid-beta protein, a key molecule in Alzheimer's disease research. This compound is crucial for studying the structural and pathological effects of specific amino acid substitutions within the amyloid-beta sequence. It is primarily utilized by academic researchers, pharmaceutical R&D teams, and diagnostic developers focused on neurodegenerative diseases, enabling advanced studies into aggregation mechanisms and potential therapeutic interventions.

Application

• Biomedical Research: Fundamental studies on the aggregation kinetics, toxicity, and structural biology of amyloid-beta peptides in Alzheimer's disease models.
• Drug Discovery & Screening: Used as a target or reference standard in high-throughput assays to identify and validate novel inhibitors of amyloid-beta aggregation.
• Antibody & Diagnostic Development: Serves as a critical antigen for the production and characterization of site-specific antibodies, as well as for calibrating immunoassays and biosensors.
• Structural Studies: Employed in techniques like NMR spectroscopy, X-ray crystallography, and electron microscopy to elucidate the impact of the Asp37 modification on peptide conformation.
• Cell Culture & In Vitro Models: Used to treat neuronal cell cultures to induce and study amyloid-β-related cytotoxicity and cellular pathways.
• Biophysical Characterization: Analysis of peptide-lipid interactions, membrane disruption, and fibril formation using techniques like surface plasmon resonance (SPR) and atomic force microscopy (AFM).

Basic Information

Product Name	(Asp37)-Amyloid B-Protein (1-42) Trifluoroacetate
CAS No.	1875128-79-2
Molecular Formula	C203H311N55O60S • xC2HF3O2
Molecular Weight	4514.0 g/mol (free base, approximate)
Synonyms	Aβ(1-42) Asp37 variant; Amyloid β-Peptide (1-42) (human) Asp37 isomer; Aβ42 Asp37; Asp37-Aβ42; Amyloid Beta Protein Fragment 1-42 (Asp37); (Asp37)-Aβ(1-42); (Asp37)-Amyloid β-Protein (1-42); H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-OH (Trifluoroacetate salt)
EINECS	Contact for details

Quality Control

Our peptide products are manufactured and analyzed under stringent quality systems suitable for research use. Each batch of (Asp37)-Amyloid B-Protein (1-42) Trifluoroacetate is characterized by advanced analytical techniques to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing purity by HPLC, mass spectrometry (MS) confirmation, and peptide content are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. Aliquot into single-use quantities to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass confirmed by ESI-TOF or MALDI-TOF
Purity (HPLC)	≥ 95%
Peptide Content	≥ 70% (by amino acid analysis)
Solubility	Soluble in 1% acetic acid or DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.