Description

1-(3-Aminoazetidin-1-Yl)-2,2,2-Trifluoroethan-1-One Hydrochloride is a high-purity, advanced pharmaceutical intermediate characterized by its unique azetidine and trifluoroacetyl motifs. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers focused on developing new therapeutics, particularly in areas requiring fluorinated bioactive molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and infectious diseases.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its trifluoromethyl group, which can enhance metabolic stability and bioavailability.
• Protease Inhibitor Development: Serves as a precursor for compounds designed to inhibit specific enzymes, such as proteases involved in viral replication or other disease pathways.
• Fluorinated Compound Library Synthesis: Essential for creating diverse screening libraries for high-throughput screening (HTS) in drug discovery programs.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the cGMP production of clinical trial materials.
• Agrochemical Research: Potential application in the development of new fluorinated agrochemicals, such as herbicides or fungicides.

Basic Information

Product Name	1-(3-Aminoazetidin-1-Yl)-2,2,2-Trifluoroethan-1-One Hydrochloride
CAS No.	1864051-98-8
Molecular Formula	C5H8F3N2O·HCl
Molecular Weight	208.58 (Free base) / 245.04 (HCl salt)
Synonyms	1-(3-Aminoazetidin-1-yl)-2,2,2-trifluoroethanone hydrochloride; 2,2,2-Trifluoro-1-(3-amino-1-azetidinyl)ethanone hydrochloride; 3-Amino-1-(2,2,2-trifluoroacetyl)azetidine hydrochloride; 1-(3-Aminoazetidin-1-yl)-2,2,2-trifluoroethanone HCl; Trifluoroacetyl-3-aminoazetidine hydrochloride; Azetidine-3-amine, 1-(trifluoroacetyl)-, hydrochloride; 3-Aminoazetidine trifluoroacetamide hydrochloride
EINECS	Contact for details

Quality Control

Our 1-(3-Aminoazetidin-1-Yl)-2,2,2-Trifluoroethan-1-One Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our quality standards are designed to meet the stringent requirements of pharmaceutical R&D and pre-clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) in the original sealed container to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.