Description

2-Azetidinecarboxylic Acid, 1-(2-Fluoroethyl)-, Methyl Ester, (2S)- is a high-purity, chiral azetidine derivative, a critical building block in modern pharmaceutical synthesis. Its unique four-membered azetidine ring and fluorine-containing side chain make it a valuable scaffold for developing novel bioactive molecules with enhanced metabolic stability and binding affinity. This compound is essential for medicinal chemistry research and process development in the pharmaceutical industry, particularly for creating targeted therapies and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and oncology research.
• Protease Inhibitor Development: Used in constructing scaffolds for inhibitors targeting various proteases due to the constrained azetidine ring.
• PET (Positron Emission Tomography) Tracer Precursor: The fluorine atom and azetidine structure make it a potential precursor for radiolabeled compounds used in diagnostic imaging.
• Medicinal Chemistry & SAR Studies: Employed to explore structure-activity relationships by introducing conformational constraint and fluorine atoms into lead compounds.
• Peptidomimetics: Serves as a proline mimetic or a constrained amino acid analogue in the design of peptide-like molecules with improved pharmacological properties.
• Chemical Biology Probes: Utilized in the development of chemical probes to study enzyme function and biological pathways.

Basic Information

Item	Detail
Product Name	2-Azetidinecarboxylic Acid, 1-(2-Fluoroethyl)-, Methyl Ester, (2S)-
CAS No.	1860033-52-8
Molecular Formula	C7H12FNO2
Molecular Weight	161.17 g/mol
Synonyms	(2S)-1-(2-Fluoroethyl)azetidine-2-carboxylic acid methyl ester; Methyl (2S)-1-(2-fluoroethyl)azetidine-2-carboxylate; (S)-1-(2-Fluoroethyl)azetidine-2-carboxylic acid methyl ester; 1-(2-Fluoroethyl)-L-azetidine-2-carboxylic acid methyl ester; Azetidine-2-carboxylic acid, 1-(2-fluoroethyl)-, methyl ester, (2S)-; L-Azetidine-2-carboxylic acid, 1-(2-fluoroethyl)-, methyl ester; Fluorinated azetidine ester
EINECS	Contact for details

Quality Control

Our 2-Azetidinecarboxylic Acid, 1-(2-Fluoroethyl)-, Methyl Ester, (2S)- is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles. We adhere to cGMP principles where applicable to support our clients' regulatory requirements from preclinical to commercial stages.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.