Description

(2R)‐2‐{[(Tert‐Butoxy)Carbonyl]Amino}‐2‐Cycloheptylacetic Acid is a high-purity, chiral Boc-protected amino acid derivative. This compound is a critical building block in the synthesis of complex peptides and peptidomimetics, offering precise stereochemical control. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of active pharmaceutical ingredients (APIs), particularly for peptide-based drugs.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) as a protected amino acid building block to introduce the cycloheptylalanine moiety.
• Protease Inhibitor Development: Serves as a core structure in the design and synthesis of protease inhibitors due to its unique aliphatic side chain.
• Chemical Biology Research: Employed in the study of protein-protein interactions and the creation of custom peptide libraries for screening.
• Bioconjugation: Utilized for the site-specific modification of peptides and proteins, enabling the creation of antibody-drug conjugates (ADCs) and other bioconjugates.
• Material Science: Acts as a monomer or modifier in the synthesis of specialized polymers with tailored biological or structural properties.

Basic Information

Product Name	(2R)‐2‐{[(Tert‐Butoxy)Carbonyl]Amino}‐2‐Cycloheptylacetic Acid
CAS No.	1860033-48-2
Molecular Formula	C₁₄H₂₅NO₄
Molecular Weight	271.35 g/mol
Synonyms	(R)-2-((tert-Butoxycarbonyl)amino)-2-cycloheptylacetic acid; Boc-Cyh-OH; Boc-C7Ala-OH; (R)-2-(Boc-amino)-2-cycloheptylacetic acid; N-Boc-L-cycloheptylglycine; N-(tert-Butoxycarbonyl)-L-cycloheptylglycine; (2R)-2-[[(2-Methylpropan-2-yl)oxycarbonyl]amino]-2-cycloheptylacetic acid
EINECS	Contact for details

Quality Control

Our (2R)‐2‐{[(Tert‐Butoxy)Carbonyl]Amino}‐2‐Cycloheptylacetic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting standards for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. For long-term storage, consider storing at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.