Description

(E)-5-(3-Ethoxy-3-Oxoprop-1-Enyl)-2-Fluorophenylboronic Acid is a high-purity, advanced pharmaceutical intermediate and building block featuring a strategically functionalized boronic acid group. This compound matters for its critical role in modern synthetic chemistry, particularly in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl structures essential for drug discovery. It is primarily needed by R&D scientists and process chemists in the pharmaceutical, agrochemical, and material science industries for developing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, especially those containing fluorinated biaryl motifs.
• Suzuki-Miyaura Cross-Coupling Reagent: Enables carbon-carbon bond formation to create complex, functionalized biaryl compounds in medicinal and process chemistry.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides that require specific fluorinated aromatic structures.
• Material Science & OLED Development: Serves as a precursor for creating organic electronic materials, including charge-transport layers and emissive materials in OLED displays.
• Chemical Biology & Probe Synthesis: Utilized for labeling and modifying biomolecules or creating fluorescent probes and sensors for research.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up manufacturing under cGMP conditions.

Basic Information

Product Name	(E)-5-(3-Ethoxy-3-Oxoprop-1-Enyl)-2-Fluorophenylboronic Acid
CAS No.	1855897-91-4
Molecular Formula	C11H12BFO4
Molecular Weight	237.02 g/mol
Synonyms	2-Fluoro-5-[(1E)-3-ethoxy-3-oxoprop-1-en-1-yl]phenylboronic acid; (E)-3-(3-Borono-4-fluorophenyl)acrylic acid ethyl ester; 5-(2-Carbethoxyvinyl)-2-fluorobenzeneboronic acid; Ethyl (E)-3-(3-borono-4-fluorophenyl)acrylate; 2-Fluoro-5-[(E)-3-ethoxy-3-oxo-1-propenyl]benzeneboronic acid; 2-Fluorophenylboronic acid derivative; Fluorinated phenylboronic acid ester; Suzuki coupling building block CAS 1855897-91-4
EINECS	Contact for details

Quality Control

Our (E)-5-(3-Ethoxy-3-Oxoprop-1-Enyl)-2-Fluorophenylboronic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed specifications are available upon request to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.